Results 81 to 90 of about 166,175,756 (300)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Multivariate goodness-of-fit tests based on kernel density estimators
Nonlinear Analysis, 2015 The paper is devoted to multivariate goodness-of-fit ests based on kernel density estimators. Both simple and composite null hypotheses are investigated.
Aleksej Bakshaev, Rimantas Rudzkis
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Limited and full information estimation and goodness-of-fit testing in 2n contingency tables [PDF]
(WP 14/03 Clave pdf)High-dimensional contingency tables tend to be sparse and standard goodness-of-fit statistics such as X 2 cannot be used without pooling categories.As an improvement on arbitrary pooling, for goodness-of-fit of large 2 n contingency ...
ALBERTO MAYDEU
core
Comparing generative models with the new physics learning machine
Nuclear Physics BThe rise of generative models for scientific research calls for the development of new methods to evaluate their fidelity. A natural framework for addressing this problem is two-sample hypothesis testing, namely the task of determining whether two data ...
Samuele Grossi +2 more
doaj +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Limited Information Goodness-Of-Fit Testing In Multidimensional Contingency Tables [PDF]
We introduce a family of goodness-of-fit statistics for testing composite null hypotheses in multidimensional contingency tables of arbitrary dimensions. These statistics are quadratic forms in marginal residuals up to order r.
ALBERTO MAYDEU
core
A GOODNESS OF FIT TEST FOR ERGODIC MARKOV PROCESSES [PDF]
We introduce a goodness of fit test for ergodic Markov processes. Our test compares the data against the set of stationary densities implied by the class of models specified in the null hypothesis, and rejects if no model in the class yields a stationary
Vance Martin +2 more
core +2 more sources