Results 61 to 70 of about 166,175,756 (300)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Asymptotic properties of a goodness-of-fit test based on maximum correlations [PDF]
, 2008 We study the efficiency properties of the goodness-of-fit test based on the Qn statistic introduced in Fortiana and Grané (2003) using the concepts of Bahadur asymptotic relative efficiency and Bahadur asymptotic optimality.
Tchirina, Anna V. +2 more
core +1 more source
Austrian Journal of Statistics, 2016 The left-truncated Weibull distribution is used in life-time analysis, it has many applications ranging from financial market analysis and insurance claims to the earthquake inter-arrival times.
Ayse KIZILERSU +2 more
doaj +1 more source
A Correlation Type Goodness of Fit Test for the Burr Distribution [PDF]
The Egyptian Statistical Journal, 1996 The Burr family of distributions is widely used in life testing studies. The two common survival or failure-time distributions, the Weibull and the Exponential, are both special cases or limiting cases of the Burr type XII (see Lewis (1981), denoted by ...
Abd-Allah Abd-Elfattah
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Made to measure? Europeanization, goodness of fit and adaptation pressures in EU competition policy and regional aid [PDF]
, 2006 Increasing attention has been devoted to understanding the process and outcomes of Europeanization, but the measurement of its impact and of the adaptational pressures involved remains elusive. Conventional constructs of Europeanization view 'goodness of
Wishlade, F.G. +4 more
core +3 more sources
Construction of a geographically weighted nonparametric regression model fit test
MethodsXOne of the approach of Geographically Weighted Regression (GWR) models is the Geographically Weighted Nonparametric Regression (GWNR) has more parameters than the GWR model.
Lilis Laome +2 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Robustness of the Trinormal ROC Surface Model: Formal Assessment via Goodness-of-Fit Testing
StatsReceiver operating characteristic (ROC) surfaces provide a natural extension of ROC curves to three-class diagnostic problems. A key summary index is the volume under the surface (VUS), representing the probability that a randomly chosen observation from
Christos Nakas
doaj +1 more source