Results 151 to 160 of about 375,535 (333)

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang   +10 more
wiley   +1 more source

Quantifying regional low flows under data scarce conditions

open access: yesHeliyon
Estimating low flow quantiles is essential for regulating minimum flow requirements and ensuring water availability, ecological health, and overall system sustainability. This study aims to quantify regional low flows by analyzing low-flow time series in
Tarekegn Dejen Mengistu   +3 more
doaj   +1 more source

A Multi-Aspect Permutation Test for Goodness-of-Fit Problems [PDF]

open access: gold, 2022
Rosa Arboretti   +5 more
openalex   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini   +28 more
wiley   +1 more source

Goodness-of-fit test for isochrone fitting in the Gaia era [PDF]

open access: bronze, 2021
G. Valle   +2 more
openalex   +1 more source

Goodness-of-fit tests for a heavy tailed distribution [PDF]

open access: yes
For testing whether a distribution function is heavy tailed, we study theKolmogorov test, Berk-Jones test, score test and their integratedversions. A comparison is conducted via Bahadur efficiency and simulations.The score test and the integrated score ...
Koning, A.J., Peng, L.
core   +1 more source

Location‐Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early neurological deterioration (END) adversely affects outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to determine the location‐specific hematoma volumes for END in supratentorial ICH patients. Methods We retrospectively analyzed supratentorial ICH patients presenting from two prospective cohorts.
Zuoqiao Li   +10 more
wiley   +1 more source

Low Incidence of Relapses After Vaccination in Anti‐Aquaporin‐4 Antibody‐Positive NMOSD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Patients with neuromyelitis optica spectrum disorder (NMOSD) may experience increased signs and symptoms of their underlying disease when vaccinated against meningococcal disease before receiving complement component 5 inhibitor therapies. This retrospective analysis indicated an overall low relapse incidence (mean [range], 3.3% [0.7%–10.6 ...
Sean J. Pittock   +4 more
wiley   +1 more source

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