Results 61 to 70 of about 369,312 (287)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Water Science and Engineering, 2013 The question of how to choose a copula model that best fits a given dataset is a predominant limitation of the copula approach, and the present study aims to investigate the techniques of goodness-of-fit tests for multi-dimensional copulas. A goodness-of-
Ming-wei Ma +4 more
doaj +1 more source
Testing for goodness rather than lack of fit of continuous probability distributions.
PLoS ONE, 2021 The vast majority of testing procedures presented in the literature as goodness-of-fit tests fail to accomplish what the term is promising. Actually, a significant result of such a test indicates that the true distribution underlying the data differs ...
Stefan Wellek
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Revstat Statistical Journal, 2018 Several procedures have been proposed for testing goodness-of-fit to the error distribution in nonparametric regression models. The null distribution of the associated test statistics is usually approximated by means of a parametric bootstrap which ...
G.I. Rivas-Martínez +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
BMC Medical Research Methodology, 2020 Background Due to limited duration of follow up in clinical trials of cancer treatments, estimates of lifetime survival benefits are typically derived using statistical extrapolation methods.
Ash Bullement +5 more
doaj +1 more source
Conditional limit laws for goodness-of-fit tests
, 2012 We study the conditional distribution of goodness of fit statistics of the Cram\'{e}r--von Mises type given the complete sufficient statistics in testing for exponential family models.
Lockhart, Richard A.
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Multimodel Response Assessment for Monthly Rainfall Distribution in Some Selected Indian Cities Using Best Fit Probability as a Tool [PDF]
, 2018 We carry out a study of the statistical distribution of rainfall precipitation data for 20 cites in India. We have determined the best-fit probability distribution for these cities from the monthly precipitation data spanning 100 years of observations ...
Desai, Shantanu +2 more
core +2 more sources