Results 61 to 70 of about 166,786,075 (302)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Benford's Law and Possibilities for Its Use in Governmental Statistics [PDF]
Statistika: Statistics and Economy Journal, 2015 Benford's Law (sometimes also called Benford's Distribution or Benford's Test) is one of the possible tools for verification of a data structure in a given file regarding the relative frequencies of occurrence of the fi rst (or second, etc.) digit from ...
Richard Hindls, Stanislava Hronová
doaj
On Entropy Test for Conditionally Heteroscedastic Location-Scale Time Series Models
Entropy, 2017 This study considers the goodness of fit test for a class of conditionally heteroscedastic location-scale time series models. For this task, we develop an entropy-type goodness of fit test based on residuals.
Sangyeol Lee, Minjo Kim
doaj +1 more source
A goodness of fit measure related to r² for model performance assessment [PDF]
, 2013 Checking the predictive worth of an environmental model inevitably includes a goodness of fit metric to quantify the degree of matching to recorded data, thereby giving a measure of model performance. Considerable analysis and discussion have taken place
Bardsley, W. Earl
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A GOODNESS OF FIT TEST FOR ERGODIC MARKOV PROCESSES [PDF]
We introduce a goodness of fit test for ergodic Markov processes. Our test compares the data against the set of stationary densities implied by the class of models specified in the null hypothesis, and rejects if no model in the class yields a stationary
Vance Martin +2 more
core +2 more sources
Frontiers in Psychology, 2018 The performance of the limited-information statistic M2 for diagnostic classification models (DCMs) is under-investigated in the current literature. Specifically, the investigations of M2 for specific DCMs rather than general modeling frameworks are ...
Fu Chen, Yanlou Liu, Tao Xin, Ying Cui
doaj +1 more source