Results 31 to 40 of about 4,865,414 (349)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Risk Analysis of Per- and Polyfluorinated Alkyl Substances in Leather Products
Pige Kexue Yu GongchengPer- and polyfluoroalkyl substances (PFAS) have been widely employed in leather processing due to their exceptional water- and oil-repellent properties, yet their environmental persistence and bioaccumulative characteristics pose potential threats to ...
Keshuai REN +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Keynesian Theory in "Macroeconomics" Course for non-core faculties
Vestnik MGIMO-Universiteta, 2016 The article deals with the issues related to the teaching of Keynesian theory within the scope of macroeconomics course at the faculties of non-economic professions.
Tatyana Ivanovna Kurnosova +1 more
doaj +2 more sources
Industry of Children’s Toys and Trends on Toy Market in the EU and Russia
Вестник Российского экономического университета имени Г. В. Плеханова, 2022 The article shows commodity expertise aspects of children’s goods market, in particular children’s toys. Demographic and economic factors are called as major ones for the development of global and Russian market of children’s goods.
S. L. Kalachev, I. A. Makhotina
doaj +1 more source
Kinetic models for goods exchange in a multi-agent market
, 2017 We introduce a system of kinetic equations describing an exchange market consisting of two populations of agents (dealers and speculators) expressing the same preferences for two goods, but applying different strategies in their exchanges.
Brugna, Carlo, Toscani, Giuseppe
core +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
A Methodological Approach to Assessing the Development of the Internal Market for Goods [PDF]
Problemi Ekonomiki, 2018 The aim of the article is to study the formation of a methodological approach to assessing the development character of the internal market for goods, which combines methods for assessing the state of the internal market for goods and methods for ...
Mardus Nataliia Yu.
doaj
Gray Market Goods: A Lighter Shade of Black Symposium: The Controversy over the Importation of Gray Market Goods: Is a Resolution Forthcoming [PDF]
, 1987 If a street vendor offers a famous brand-name product for a substantially lower price than one would expect, the average consumer\u27s initial reaction might be that the product had been stolen or was hot - a product of the black market.
Hansen, Hugh C.
core +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source