Results 131 to 140 of about 6,673 (189)

Gossypol Toxicity and Detoxification in Helicoverpa armigera and Heliothis virescens

Insect Biochemistry and Molecular Biology, 2016
Gossypol is a polyphenolic secondary metabolite produced by cotton plants, which is toxic to many organisms. Gossypol's aldehyde groups are especially reactive, forming Schiff bases with amino acids of proteins and cross-linking them, inhibiting enzyme ...
Wilhelm Boland, David G Heckel, Heiko Vogel   +2 more
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Gossypol and hypokalaemia

Contraception, 1985
One major side effect of administration of gossypol as a male fertility regulating agent is the occurrence of hypokalaemic paralysis. We have reviewed the common causes of hypokalaemia in clinical practice and previous studies of gossypol-induced hypokalaemia in animals and man.
C, Wang, R T, Yeung
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The toxicology of gossypol acetic acid and (−)-gossypol

Contraception, 1988
The toxicity of gossypol has been investigated in Sprague-Dawley rats at dosages of 0, 0.5, 5.0 and 25 mg/kg per day of (+/-)-gossypol acetic acid. The most significant toxicological finding was marked suppression of body weight gain in rats receiving 25 mg/kg per day.
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Synthesis of gossypol and gossypol derivatives

Journal of the American Oil Chemists' Society, 1970
AbstractThe synthesis of gossypol and certain major degradation products possessing the binaphthyl ring carbon skeleton is discussed.
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Antifertility effect of polyvinylpyrrolidone-gossypol and gossypol in male rats

Contraception, 1985
Thirty-nine adult male Wistar rats were administered 20 mg/kg or 24.3 mg/kg polyvinylpyrrolidone-gossypol (PVP-G) and 20 mg/kg gossypol acetic acid (G-A) 6 times a week for 6 weeks. Mating test was taken to evaluate the antifertility effect. Caudal sperm count, body weight, sex and accessory sex organ weights were recorded.
Y, Wang, X Q, Shi, Y B, Sun
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Comparative in vitro spermicidal effects of (+/-)-gossypol, (+)-gossypol, (-)-gossypol and gossypolone.

Contraception, 1985
The comparative in vitro spermicidal effects of (+)-gossypol, (-)-gossypol and (+/-)-gossypol were evaluated on the spermatozoa of human, monkey, rabbit, mouse, rat and hamster. The spermicidal effects of gossypol isomers were also compared with those of gossypolone, which is a proposed major metabolite of gossypol.
I C, Kim, D P, Waller, G B, Marcelle, G A, Cordell, H H, Fong, W H, Pirkle, L, Pilla, S A, Matlin   +7 more
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Interaction of gossypol with DNA

Toxicology in Vitro, 1992
Gossypol, a polyphenolic binaphthyl dialdehyde found in cotton seeds, is a dietary mutagen and a potential male contraceptive. Its interaction with DNA was studied using a combination of S(1) nuclease hydrolysis and hydroxyapatite chromatography. Calf thymus DNA treated with increasing concentrations of gossypol showed a decreasing degree of S(1 ...
R, Zaidi, S M, Hadi
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Metabolic fate of gossypol: The metabolism of [14C]gossypol in swine

Toxicology and Applied Pharmacology, 1975
Balance studies designed to obtain information concerning the metabolic fate of gossypol in rats were carried out utilizing two groups of animals. One was fed a basal diet and the other the same diet plus 500 ppm of iron as FeSO4. Single doses of 5 mg each of14C-labeled gossypol (spec. act. 19.8 μCi/mmole) were administered. The animals were maintained
M B, Abou-Donia, J W, Dieckert
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Metabolism of gossypol in the chick

Journal of the American Oil Chemists' Society, 1969
Abstract14C labeled gossypol was administered to young chickens and the deposition of gossypol plus gossypol decomposition products in the various tissues was evaluated by determination of14C activity in a scintillation spectrometer. Most of the gossypol activity was recovered in the feces with relatively smaller amounts retained by the tissues.
C M, Lyman, J T, Cronin, M M, Trant, G V, Odell   +3 more
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Gossypol Detoxication by Fungi

Science, 1969
An unidentified Diplodia isolate representative of several fungi tested and grown for 13 days on gossypol-containing cottonseed reduced the amount of free gossypol by 90 percent and detoxified the cottonseed for weanling rats and chickens.
W L, Baugher, T C, Campbell
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