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Inhibition of Aldose Reductase by Gossypol and Gossypol-Related Compounds
1999The aldo-keto reductases are a widely distributed family of oxidoreductases (Wirth and Wermuth, 1985; Wermuth, 1985; Grimshaw and Mathur, 1989). Aldose reductase (EC 1.1.1.21; ALR2; or AKR1B1 (Jez et al., 1997)), which has a role in the etiology of diabetic complications (Gabbay, 1973; Kador and Kinoshita, 1985), has received most attention as a ...
L M, Deck +4 more
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Gossypol Clathrates. Structure of a Gossypol Complex with Isobutylacetate
Journal of Structural Chemistry, 2002The natural compound gossypol forms stable clathrates with isobutylacetate. The clathrates were investigated by X-ray diffractometry. The crystallographic parameters of single crystals were determined and refined using 15 reflections on a Syntex P21 four-circle automatic diffractometer. The crystals are monoclinic, C30H30O8·0.5C6H12O2, a = 11.444(2), b
S. A. Talipov, B. T. Ibragimov
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Hepatotoxicity of gossypol in rats
Journal of Ethnopharmacology, 1987Gossypol acetic acid (GAA) at the dosage of 30 mg/kg daily for 2 weeks could prolong the sleeping time of pentobarbital, increase the SGPT level, decrease the liver concentration of cytochrome P-450 and GSH content, inhibit the activity of cytochrome C reductase and aminopyrine-N-demethylase, but was without effect on cytochrome b5 and aniline ...
Y, Wang, H P, Lei
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2000
Abstract Gossypol is a yellow pigment from the cotton plant flower of Thespesia popular Soland., and the seed and root of Gossypium herbaceum L. In the 1960s, gossypol was found to be a cause of male infertility in many rural areas of China (9), where ingestion of raw cotton seed oil was common.
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Abstract Gossypol is a yellow pigment from the cotton plant flower of Thespesia popular Soland., and the seed and root of Gossypium herbaceum L. In the 1960s, gossypol was found to be a cause of male infertility in many rural areas of China (9), where ingestion of raw cotton seed oil was common.
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Journal of the American Oil Chemists' Society, 1968
AbstractMuch of the «free» gossypol in meals of low free gossypol content consists of «soluble‐bound» gossypol. Addition of dilute hydrochloric acid reduces the optical densities of gossypol blanks in free and total gossypol calibrations and assays. The reductions in these optical densities were lower than expected in free gossypol assays on meals of ...
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AbstractMuch of the «free» gossypol in meals of low free gossypol content consists of «soluble‐bound» gossypol. Addition of dilute hydrochloric acid reduces the optical densities of gossypol blanks in free and total gossypol calibrations and assays. The reductions in these optical densities were lower than expected in free gossypol assays on meals of ...
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Reactions of proteins with gossypol
Archives of Biochemistry and Biophysics, 1959Abstract Several methods for the preparation of protein-gossypol complexes are described. When gossypol combines with blood albumin or with cottonseed protein, the reaction is with the free e-amino groups of lysine. The ratio of moles of free lysine ϵ-amino groups which disappear to moles of gossypol combined with protein varies according to the ...
C M, LYMAN, B P, BALIGA, M W, SLAY
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Gossypol‐hypokalaemia interrelationships
International Journal of Andrology, 1985Around 1% of 8806 volunteers taking gossypol as a male contraceptive had hypokalaemic paralysis and more had simple hypokalaemia, the direct cause being renal potassium loss. In gossypol takers not showing hypokalaemia, serum potassium levels were within the normal range but were significantly lower than levels in controls.
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Gossypol as a Toxicant in Livestock
Veterinary Clinics of North America: Food Animal Practice, 1989Many cases of gossypol toxicity have been misdiagnosed. The long-held belief that gossypol toxicity did not occur in ruminants has been a major hurdle to overcome. Field necropsies in which pulmonary congestion and edema were attributed to shipping-fever pneumonia, failure to examine the heart either grossly or microscopically, failure to believe that ...
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Comparative spermicidal effects of (+)-gossypol, (+)-gossypol, (−)-gossypol and gossypolone
Contraception, 1984I.C. Kim +7 more
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