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Neuroprotective and anti-inflammatory activity of <i>Wyethia</i> species: therapeutic potential for neurodegenerative diseases. [PDF]

Front Pharmacol
Sagbo IJ, Soriano-Castell D, Rebman J, Maher P.   +3 more
europepmc   +1 more source

Sea Buckthorn Pericarp Flavonoids Improve Diet-Induced Hyperlipidemia via Coordinated Modulation of Hepatic Lipid Metabolism and Gut Microbiota. [PDF]

Foods
Bao X, Wang Q, Li F, Wu T, Mou X, Zeng Q, Jia M.   +6 more
europepmc   +1 more source

Gossypol, a natural product has good antimalarial activity of against Plasmodium falciparum clinical isolates

Chirawurah JD, Ansah F, Amenga-Etego L, Awandare GA, Aniweh Y, Blankson S, Adikah B.   +6 more
europepmc   +1 more source

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Gossypol and hypokalaemia

Contraception, 1985
One major side effect of administration of gossypol as a male fertility regulating agent is the occurrence of hypokalaemic paralysis. We have reviewed the common causes of hypokalaemia in clinical practice and previous studies of gossypol-induced hypokalaemia in animals and man.
C, Wang, R T, Yeung
openaire   +2 more sources

The toxicology of gossypol acetic acid and (−)-gossypol

Contraception, 1988
The toxicity of gossypol has been investigated in Sprague-Dawley rats at dosages of 0, 0.5, 5.0 and 25 mg/kg per day of (+/-)-gossypol acetic acid. The most significant toxicological finding was marked suppression of body weight gain in rats receiving 25 mg/kg per day.
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Synthesis of gossypol and gossypol derivatives

Journal of the American Oil Chemists' Society, 1970
AbstractThe synthesis of gossypol and certain major degradation products possessing the binaphthyl ring carbon skeleton is discussed.
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Antifertility effect of polyvinylpyrrolidone-gossypol and gossypol in male rats

Contraception, 1985
Thirty-nine adult male Wistar rats were administered 20 mg/kg or 24.3 mg/kg polyvinylpyrrolidone-gossypol (PVP-G) and 20 mg/kg gossypol acetic acid (G-A) 6 times a week for 6 weeks. Mating test was taken to evaluate the antifertility effect. Caudal sperm count, body weight, sex and accessory sex organ weights were recorded.
Y, Wang, X Q, Shi, Y B, Sun
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Comparative in vitro spermicidal effects of (+/-)-gossypol, (+)-gossypol, (-)-gossypol and gossypolone.

Contraception, 1985
The comparative in vitro spermicidal effects of (+)-gossypol, (-)-gossypol and (+/-)-gossypol were evaluated on the spermatozoa of human, monkey, rabbit, mouse, rat and hamster. The spermicidal effects of gossypol isomers were also compared with those of gossypolone, which is a proposed major metabolite of gossypol.
I C, Kim, D P, Waller, G B, Marcelle, G A, Cordell, H H, Fong, W H, Pirkle, L, Pilla, S A, Matlin   +7 more
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Interaction of gossypol with DNA

Toxicology in Vitro, 1992
Gossypol, a polyphenolic binaphthyl dialdehyde found in cotton seeds, is a dietary mutagen and a potential male contraceptive. Its interaction with DNA was studied using a combination of S(1) nuclease hydrolysis and hydroxyapatite chromatography. Calf thymus DNA treated with increasing concentrations of gossypol showed a decreasing degree of S(1 ...
R, Zaidi, S M, Hadi
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