Results 171 to 180 of about 11,071 (224)

Metabolism of gossypol in the chick

Journal of the American Oil Chemists' Society, 1969
Abstract14C labeled gossypol was administered to young chickens and the deposition of gossypol plus gossypol decomposition products in the various tissues was evaluated by determination of14C activity in a scintillation spectrometer. Most of the gossypol activity was recovered in the feces with relatively smaller amounts retained by the tissues.
C M, Lyman, J T, Cronin, M M, Trant, G V, Odell   +3 more
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Metabolic fate of gossypol: The metabolism of [14C]gossypol in swine

Toxicology and Applied Pharmacology, 1975
Balance studies designed to obtain information concerning the metabolic fate of gossypol in rats were carried out utilizing two groups of animals. One was fed a basal diet and the other the same diet plus 500 ppm of iron as FeSO4. Single doses of 5 mg each of14C-labeled gossypol (spec. act. 19.8 μCi/mmole) were administered. The animals were maintained
M B, Abou-Donia, J W, Dieckert
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Gossypol Detoxication by Fungi

Science, 1969
An unidentified Diplodia isolate representative of several fungi tested and grown for 13 days on gossypol-containing cottonseed reduced the amount of free gossypol by 90 percent and detoxified the cottonseed for weanling rats and chickens.
W L, Baugher, T C, Campbell
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Inhibition of Aldose Reductase by Gossypol and Gossypol-Related Compounds

1999
The aldo-keto reductases are a widely distributed family of oxidoreductases (Wirth and Wermuth, 1985; Wermuth, 1985; Grimshaw and Mathur, 1989). Aldose reductase (EC 1.1.1.21; ALR2; or AKR1B1 (Jez et al., 1997)), which has a role in the etiology of diabetic complications (Gabbay, 1973; Kador and Kinoshita, 1985), has received most attention as a ...
L M, Deck, B B, Chamblee, R E, Royer, L A, Hunsaker, D L, Vander Jagt   +4 more
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Gossypol Clathrates. Structure of a Gossypol Complex with Isobutylacetate

Journal of Structural Chemistry, 2002
The natural compound gossypol forms stable clathrates with isobutylacetate. The clathrates were investigated by X-ray diffractometry. The crystallographic parameters of single crystals were determined and refined using 15 reflections on a Syntex P21 four-circle automatic diffractometer. The crystals are monoclinic, C30H30O8·0.5C6H12O2, a = 11.444(2), b
S. A. Talipov, B. T. Ibragimov
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Hepatotoxicity of gossypol in rats

Journal of Ethnopharmacology, 1987
Gossypol acetic acid (GAA) at the dosage of 30 mg/kg daily for 2 weeks could prolong the sleeping time of pentobarbital, increase the SGPT level, decrease the liver concentration of cytochrome P-450 and GSH content, inhibit the activity of cytochrome C reductase and aminopyrine-N-demethylase, but was without effect on cytochrome b5 and aniline ...
Y, Wang, H P, Lei
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Reactions of proteins with gossypol

Archives of Biochemistry and Biophysics, 1959
Abstract Several methods for the preparation of protein-gossypol complexes are described. When gossypol combines with blood albumin or with cottonseed protein, the reaction is with the free e-amino groups of lysine. The ratio of moles of free lysine ϵ-amino groups which disappear to moles of gossypol combined with protein varies according to the ...
C M, LYMAN, B P, BALIGA, M W, SLAY
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Gossypol‐hypokalaemia interrelationships

International Journal of Andrology, 1985
Around 1% of 8806 volunteers taking gossypol as a male contraceptive had hypokalaemic paralysis and more had simple hypokalaemia, the direct cause being renal potassium loss. In gossypol takers not showing hypokalaemia, serum potassium levels were within the normal range but were significantly lower than levels in controls.
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Gossypol

2000
Abstract Gossypol is a yellow pigment from the cotton plant flower of Thespesia popular Soland., and the seed and root of Gossypium herbaceum L. In the 1960s, gossypol was found to be a cause of male infertility in many rural areas of China (9), where ingestion of raw cotton seed oil was common.
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Resolution of racemic gossypol

Journal of Ethnopharmacology, 1987
Treating racemic gossypol with chiral amine (S)-1-methylphenethyl amine gave the expected pair of diastereomeric amino condensates in which the binaphthyl nuclei racemized during further treatment. Acetylation was applied to avoid the change. On acetylation, 7 products were separated.
L, Huang, D K, Zheng, Y K, Si
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