Results 111 to 120 of about 216,147 (379)
Annals of the Rheumatic Diseases, 2015 Objective Existing criteria for the classification of gout have suboptimal sensitivity and/or specificity, and were developed at a time when advanced imaging was not available.
T. Neogi +21 more
semanticscholar +1 more source
GSK461364 Inhibits NLRP3 Inflammasome by Targeting NEK7 Phosphorylation
Advanced Science, EarlyView.Schematic diagram of the mechanism by which GSK461364 inhibits NLRP3 inflammasome activation. GSK461364 inhibits the phosphorylation of NEK7 likely at serine 221 and serine 260 by suppressing the activity of PLK1, thereby restraining the formation of the NLRP3 inflammasome.
Ruiheng Luo +13 more
wiley +1 more source
, 2018 We analyse a linear regression problem with nonconvex regularization called smoothly clipped absolute deviation (SCAD) under an overcomplete Gaussian basis for Gaussian random data.
Sakata, Ayaka, Xu, Yingying
core +1 more source
Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity
Advanced Science, EarlyView.This review explores the complex and self‐reinforcing cycle of mechanical stress, inflammation, and altered vascularity in tendinopathy—a common, painful tendon disorder. It integrates current findings on cellular, molecular, and biomechanical mechanisms, highlighting how mechanical overload, inflammatory signals, and abnormal blood vessel behavior ...
Renate Gehwolf +5 more
wiley +1 more source
Праці Наукового товариства імені Шевченка. Медичні науки, 2020 I felt a personal connection to this book before even reading it, as Danylo Halytsky Lviv National Medical University is my Alma Mater and my career path in cancer research was inspired by Prof. B. Bilynsky, who was the Head of Oncology Department during
Ivan Gout
doaj
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Chondrocalcinosis (CCAL), also known as calcium pyrophosphate dihydrate deposition disease (CPPDD), is a frequent multifactorial condition in the elderly, but there are two rare autosomal dominant Mendelian forms, CCAL1 (OMIM %600668) and CCAL2. Only three families with molecularly proven CCAL1 have been reported.
Anna‐Christina Pansa +4 more
wiley +1 more source
Annals of the Rheumatic Diseases, 2020 Objective Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1β-dependent inflammation during gout and pseudo-gout flare, respectively.
F. Renaudin +16 more
semanticscholar +1 more source
Animal Models and Experimental Medicine, EarlyView.Simplified schematic for generation of the subcutaneous air pouch model in the rodent. On day 0 and 4, air is injected into the subcutaneous space on the dorsal surface of the rodent to generate a cavity analogous to a synovial joint. On day 6, monosodium urate (MSU) or calcium pyrophosphate (CPP) crystals are injected into the pouch to stimulate ...
Wenu Hewage +4 more
wiley +1 more source
Peptide/Antibody–Drug Conjugates for Therapeutic Applications in Inflammatory Disease
Advanced NanoBiomed Research, EarlyView.Peptide/antibody–drug conjugates (PADCs) combine ligand specificity and cleavable linkers to deliver drugs precisely to disease sites with minimal toxicity. While current approvals focus on oncology, this review examines their untapped potential in inflammatory diseases, detailing mechanisms of targeted delivery and highlighting advances that position ...
Yeongji Jang +5 more
wiley +1 more source
Association of urine autoantibodies with disease activity in systemic lupus erythematosus
Frontiers in MedicineObjectiveThe presence of urinary autoantibodies in patients with systemic lupus erythematosus (SLE) has been confirmed by several studies; however, the significance of their presence in urine remains unclear.
Yuxian Zhang +6 more
doaj +1 more source