Results 111 to 120 of about 1,043,166 (320)
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld+7 more
wiley +1 more source
The Internationalization of Public Policy and the Prospects for a Theory of Multi-Level Governance [PDF]
Ian Roberge
openalex +1 more source
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou+13 more
wiley +1 more source
A Reference Model for Information Quality in an IT Governance Context [PDF]
IT Governance systems are increasingly required to keep todays organizations functioning. IT Governance requires a holistic system of interacting components, including processes, organizational structures, information, and others. Performance management of IT Governance systems is of utmost importance to maintain their effectiveness.
arxiv
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang+10 more
wiley +1 more source
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park+6 more
wiley +1 more source
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad+13 more
wiley +1 more source
Generative AI Needs Adaptive Governance [PDF]
Because of the speed of its development, broad scope of application, and its ability to augment human performance, generative AI challenges the very notions of governance, trust, and human agency. The technology's capacity to mimic human knowledge work, feedback loops including significant uptick in users, research, investor, policy, and media ...
arxiv
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou+11 more
wiley +1 more source
Transfeminist AI Governance [PDF]
This article re-imagines the governance of artificial intelligence (AI) through a transfeminist lens, focusing on challenges of power, participation, and injustice, and on opportunities for advancing equity, community-based resistance, and transformative change. AI governance is a field of research and practice seeking to maximize benefits and minimize
arxiv