Results 51 to 60 of about 1,043,166 (320)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Cost–related unmet need for healthcare services in Kenya

BMC Health Services Research, 2020
Background The assessment of unmet need is one way to gauge inequities in access to healthcare services. While there are multiple reasons for unmet need, financial barriers are a major reason particularly in low- and middle-income countries where ...
Purity Njagi, Jelena Arsenijevic, Wim Groot   +2 more
doaj   +1 more source

Putting AI Ethics into Practice: The Hourglass Model of Organizational AI Governance [PDF]

arXiv, 2022
The organizational use of artificial intelligence (AI) has rapidly spread across various sectors. Alongside the awareness of the benefits brought by AI, there is a growing consensus on the necessity of tackling the risks and potential harms, such as bias and discrimination, brought about by advanced AI technologies.
arxiv  

Corporate Governance in China: A Survey

Review of Finance, 2020
This article surveys corporate governance in China, as described in a growing literature published in top journals. Unlike the classical vertical agency problems in Western countries, the dominant agency problem in China is the horizontal agency ...
Fuxiu Jiang, Kenneth A. Kim
semanticscholar   +1 more source

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

FEBS Letters, EarlyView.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka, Takahiro Ogawa, Rikako Tsukida, Keiichi Noguchi, David Hibbett, Yoko Katayama, Makoto Yoshida   +6 more
wiley   +1 more source

Growth Mindset and Job Crafting: A Trait Activation Perspective with Job Autonomy as Moderator

Behavioral Sciences
Job crafting benefits both employees and organizations by enhancing employees’ health, well-being, and performance. Therefore, it is crucial to investigate the individual factors that encourage job crafting and the conditions under which they operate ...
Tao Yu, Lidong He, Hu Ying, Jie Liu, Yuzhen Wu, Yun Wang, Xiaofu Pan   +6 more
doaj   +1 more source

Bank Governance, Regulation, and Risk Taking

, 2008
This paper conducts the first empirical assessment of theories concerning risk taking by banks, their ownership structures, and national bank regulations. We focus on conflicts between bank managers and owners over risk, and we show that bank risk taking
L. Laeven, Ross Levine
semanticscholar   +1 more source

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

FEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R. Hall, Anton A. Stepnov, Tom Z. Emrich‐Mills, Iván Ayuso‐Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G. H. Eijsink   +10 more
wiley   +1 more source

Barriers and Levers for the Implementation of OCAP™

International Indigenous Policy Journal, 2014
This article discusses the obstacles to and supports for the implementation of the First Nations Principles of OCAP™, specifically in the context of data holdings within Aboriginal Affairs and Northern Development Canada (AANDC) and the Government of ...
First Nations Information Governance Centre
doaj