Results 181 to 190 of about 18,243 (254)

Critical Information Infrastructure Protection and Cybersecurity in New York State: Governance Models, Practices, and Crisis Escalation Procedures—A Vital Discussion for the Future of New York’s Security

Journal of Software Engineering and Applications
openaire   +1 more source

Disparities in the use of remote general practice consultations: learning from the COVID-19 pandemic, an analysis of 19 million electronic health records using OpenSAFELY. [PDF]

BMC Med
Aminu AQ, Sinclair DR, Davies K, Hall A, Wiedemann M, O'Neill TW, Clegg A, Todd C.   +7 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Dementia Data Landscape 1. Cohorts. [PDF]

Alzheimers Dement
Morgan A, Durkin C, Tari B, Squires E, Young S, Bauermeister J, Bauermeister S, Gallacher J.   +7 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

The Global Epidemiology of Antimicrobial Resistance: Trends, Determinants, and Public Health Implications. [PDF]

Cureus
Alenzi SLO, Alharthi AH, Alnefaie RA, Alzahrani A, Alsaadi O, Albugami ANM, Alhusini KM, Alanazi FS, ALAnazi FHK, Alkhayyat AA.   +9 more
europepmc   +1 more source

Departmental investment strategy 2005-08: July 2005 [PDF]

core  

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Uncovering Systemic Dynamics through an Integrated WEFE Nexus Index across 21st Century Futures. [PDF]

Environ Sci Technol
Özcan Z, Alp E.
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source