Results 61 to 70 of about 56,392 (261)

Factors affecting effective citizen-based monitoring of frontline service delivery in South Africa

Africa’s Public Service Delivery & Performance Review
Background: In South African local government, citizen-based monitoring (CBM) for frontline service delivery is pivotal for enhancing governance. Understanding the factors shaping effective CBM in this context is crucial for improving public service ...
Lesedi S. Matlala
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Reflections on the technical pathways for integrating healthy life expectancy into the national health assessment system

Shanghai yufang yixue
Integrating healthy life expectancy (HLE) into the national health assessment system is a key institutional arrangement for advancing the Healthy China Strategy from a disease-centered to a health-centered paradigm.
ZHOU Liang, ZHOU Dan, WANG Hui
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Pengaruh Corporate Governance terhadap Efektifitas Mekanisme Pengurang Masalah Agensi

Jurnal Siasat Bisnis, 2009
The main objective of this research is to investigate whether there are a significant influence between corporate governance and effectiveness of agency-problem-reducing mechanism. The corporate governance is concern on all stakeholder interest while the
Zaenal Arifin, Nina Rachmawati
doaj   +4 more sources

Data Service Providers' Participation in Data Black Market Governance Based on Evolutionary Games [PDF]

Nongye tushu qingbao xuebao
[Purpose/Significance] In the context of China's commitment to the development of the data element circulation market, the governance of the data black market has emerged as a pressing issue that demands urgent attention.
Fengling ZHANG, Xiaoqi MA
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Research on the Subjects, Structures and Mechanism of Online Health Rumors Multi-center Collaborative Governance

Zhishi guanli luntan
[Purpose/significance] Faced with the current dilemma of scattered and redundant governance of online health rumors, multiple synergy is regarded as a vital approach to improve both efficiency and ability of governance.
Chen Yanfang, Pei Junliang, Chu Jihua
doaj   +1 more source