Results 71 to 80 of about 56,392 (261)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Economic governance of property rights: comparative analysis on the collection of royalties in genetically modified soybean seeds

Revista de Economia e Sociologia Rural, 2013
This paper examines the governance of property rights on genetically modified (GM) soybean seeds. Specifically, the article undertakes a comparative analysis on the collection of royalties in GM soybean seeds in the U.S. and Brazil. For each country, the
Guilherme Fowler de Avila Monteiro, Decio Zylbersztajn   +1 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Improvement of Marine Environment Cooperative Governance Mechanism from the Perspective of Ecological Community of Common Destiny

Haiyang Kaifa yu guanli, 2022
In order to effectively respond to marine environmental pollution and improve the modernization level of marine environmental governance, this paper took Liaoning as an example, analyzed the current situation and existing problems of marine environment ...
Xiuli YU
doaj  

GOVERNING SHADOWS: GOVERNANCE MECHANISMS FOR AUTONOMOUS IT SOLUTIONS

CONTECSI International Conference on Information Systems and Technology Management, 2019
Shadow IT encompasses solutions deployed by users, outside the formal structure of IT management. The dissatisfaction with official systems is often the main motivation for the adoption of Shadow IT. Through it, users expect to streamline business processes and improve the user experience. In terms of IT governance, however, Shadow IT means a challenge.
Humberto Caetano Cardoso da Silva, Rosamaria Belo Lucena, Henrique Santos Ferreira, Jairo Simião Dornelas   +3 more
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Stakeholder governance and the CSR of banks: An analysis of an internal governance mechanism based on game theory. [PDF]

Front Psychol, 2022
An J, Di H, Yao M.
europepmc   +1 more source

Mechanisms Governing Precise Protein Biotinylation

Trends in Biochemical Sciences, 2017
Protein biotinylation is a key post-translational modification found throughout the living world. The covalent attachment of a biotin cofactor onto specific metabolic enzymes is essential for their activity. This modification is distinctive, in that it is carried out by a single enzyme: biotin protein ligase (BPL), an enzyme that is able to biotinylate
Louise M. Sternicki, Kate L. Wegener, John B. Bruning, Grant W. Booker, Steven W. Polyak   +4 more
openaire   +3 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source