Results 121 to 130 of about 2,783,596 (297)

Systems theories and systems praxis

This cutting-edge Research Handbook provides a comprehensive overview of research on the governance of ...
Sankaran, S
core  

Climate change policy, conflict and transformative governance [PDF]

, 2013
Climate change is the behemoth of our age. It defies description, is too large to comprehend, and what we do understand about it is often terrifying. This is for many, a good reason to stop thinking about it or, like Scarlett O’Hara, decide to “think ...
Melissa Nursey-Bray
core  

New Arenas of Engagement at the Water Governance-Climate Finance Nexus? An Analysis of the Boom and Bust of Hydropower CDM Projects in Vietnam

Water Alternatives, 2014
This article explores whether new arenas of engagement for water governance have been created and utilised following the implementation of the Clean Development Mechanism (CDM) in large hydropower projects in Vietnam. Initial optimism for climate finance
Mattijs Smits, Carl Middleton
doaj  

Sustainability-Driven Innovation in Engineering Project Governance Models

Journal of Engineering, Project, and Production Management
Due to the unprecedented rate of global economic and social development, the conflict between mankind, natural resources and the environment has increased. Major infrastructure projects provide significant benefits to regions.
Bojiao Lu
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Governance of collaborative projects organized as communities [PDF]

, 2018
\ Collaborative projects organized as communities have a significant participation of volunteers and are formed by individuals geographically distributed, interconnected through a technology platform in a work of mutual interest, creating and freely ...
Santos Jr., Carlos, Ferraz, Isabela
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Unfulfilled promises, illegal resource extraction, and the legitimacy of park management in Ethiopia

Ecology and Society
Protected area management in developing countries faces legitimacy issues, especially with supposed participatory governance reforms and social-ecological disturbances.
Tadesse Temesgen Taye, Temeselew Woldetsadik Mawugatie, Tafesse Kefyalew Estifanos   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

REFORMASI BIROKRASI MENUJU GOOD GOVERNANCE

, 2020
Globalization in various areas of life , especially the advancement of information technology and the transformation has encouraged the changing needs of the community , as well . encourage governments as public administration and public management to be
Indah, Diani
core