Results 131 to 140 of about 2,783,596 (297)
Project Indicators for Enhancing Governance of Projects
Procedia Technology, 2014 AbstractGovernance of projects, programmes and portfolios is an increasing research area and practice, but it is not yet considered to be as mature as it happens with project management concepts and practices. This paper presents an intermediate result from an on-going multi case research study addressing the perceived relevance of different projects ...
openaire +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Frontiers in BlockchainBlockchain is a transformative technology with the potential to metamorphose industries, including supply chains and logistics, owing to its promise of efficiency, transparency and traceability. However, many blockchain projects have failed, requiring an
Issam Najati
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Publishing Construction Contracts as a Tool for Efficiency and Good Governance - Working Paper 272 [PDF]
Construction is a $1.7 trillion industry worldwide, much of which is linked to publicly financed projects. Outcomes from this financing are frequently suboptimal.
Charles Kenny
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
A two-tiered approach to the valuation of investment projects adjusted for governance risk [PDF]
This paper sets forth a pair of distinctive contributions to the subject. In the first place, it provides a unified approach to capital investment decisions, by means of a two-tiered framework of analysis.
Rodolfo Apreda
core
Variability of enterprise architecture elements in Finnish ePrescription projects
Finnish Journal of eHealth and eWelfare, 2014 The governance of large eHealth initiatives is complicated by multiple viewpoints and autonomy of numerous different stakeholder organizations. In addition, the lifecycle of goals and requirements spans multiple different organizations, as well as ...
Hannu Virkanen +2 more
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