Results 111 to 120 of about 8,009,603 (305)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Governance Quality and Renewable Energy Transition: Global Evidence Using Panel ARDL

open access: yesEnergies
This study analyses the long-run relationship between governance quality and renewable energy development using a global panel of 174 countries over the period 2000–2023.
Oksana Liashenko   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Latent Regimes in Sustainability Transitions: How Digital Connectivity and Governance Quality Shape Development Trajectories

open access: yesWorld
Global progress towards the 2030 Sustainable Development Goals (SDGs) remains critically off track, with current trends indicating that only 17% of targets will be met by the deadline.
Oksana Liashenko   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Governance Quality and the Green Transition: Integrating Econometric and Machine Learning Evidence on Renewable Energy Efficiency in Sub-Saharan Africa

open access: yesEnergies
Renewable energy efficiency (REE) remains critically low across many Sub-Saharan African (SSA) countries, yet the existing literature provides limited empirical clarity on how governance quality shapes efficiency outcomes and through which mechanisms ...
Joseph Nyabvudzi   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Home - About - Disclaimer - Privacy