Results 81 to 90 of about 1,641,397 (256)

Federated AI for building AI Solutions across Multiple Agencies [PDF]

open access: yes, 2018
The different sets of regulations existing for differ-ent agencies within the government make the task of creating AI enabled solutions in government dif-ficult. Regulatory restrictions inhibit sharing of da-ta across different agencies, which could be a
Cirincione, Greg   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The Financial and Accounting Information: a Genuine Power Factor, in the Report Win - Loss of the Investment on the Capital Market [PDF]

open access: yesOvidius University Annals: Economic Sciences Series, 2016
The accounting information can be assimilated and analyzed based on three aspects: semantic,syntactic and pragmatic. The semantic aspect of the information refers to its importance for thereceiving element.
Claudia Nicoleta Guni
doaj  

EGovernance implementation model: Case study of the federal government agencies of Pakistan [PDF]

open access: yes, 2013
Copyright @ 2013 EMCIS.This study examines the eGovernance potential to bring about structural changes in the way in which government agencies operate, interact and communicate internally and externally with its citizens.
Arfeen, MI, Kamal, MM
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Young and Older Farmers’ Perception and Assessment of Government Agricultural Agencies in Poland [PDF]

open access: yes
This article attempts to determine significance of differences among young and older farmers’ judgments on selected performance aspects of two EU paying agencies in Poland, namely Agency for Restructuring and Modernization of Agriculture (ARMA) and ...
Zawojska, Aldona
core   +1 more source

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