Results 41 to 50 of about 2,006,808 (290)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Success and failure factors for e-government projects: A case from Egypt
Egyptian Informatics Journal, 2013 E-government implementations in developing countries still face difficulties, leading to a large failure ratio. This is too high a cost for developing countries.
Hatem Elkadi
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Genes governing premature ovarian failure [PDF]
Reproductive BioMedicine Online, 2010 Premature ovarian failure (POF) is unexplained amenorrhoea (>6 months), increased FSH (>20 IU/l) and LH occurring before 40 years. Several genes are reported as having significance in POF, including genes governing regulation of the hypothalamic-pituitary-ovarian axis, but their role in ovarian physiology is not known. Deletions or translocations in Xq
Hridesh, Dixit +12 more
openaire +2 more sources
An actor-network theory (ANT) approach to Turkish e-government gateway initiative [PDF]
, 2009 There are various models proposed in the literature to analyze trajectories of e-Government projects in terms of success and failure. Yet, only the Actor-Network Theory (ANT) perspective (Heeks and Stanforth, 2007) considers the interaction factors among
Aykac, D. Selcen O. +4 more
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Jurnal Sistem Informasi, 2015 Since Inpres No.3 of 2003 about policies and strategies for e-Government development, the Government institution was required to be able to take advantage of the progress of Information and Communication Technology (ICT) in order to improve the ...
Darmawan Baginda Napitupulu
doaj +3 more sources
Management of Oil Revenues: Has That of Azerbaijan Been Prudent?
Economies, 2017 To help explain the common failure of oil or other natural resource exporting countries to diversify into industry, it has been common to trace this failure to real exchange rate appreciation. This has also been done in Azerbaijan.
Sarvar Gurbanov +2 more
doaj +1 more source
Infrastructure Policy and Governance Failures [PDF]
SSRN Electronic Journal, 2012 Interventions to fix market failures in infrastructure have often resulted in some form of governance failure and this contributes importantly to explain shortcomings in the supply of infrastructure services in developing countries and increasingly in developed countries in crisis. The development community continues to address sector dysfunctions from
Benitez, Daniel +2 more
openaire +2 more sources