Results 51 to 60 of about 2,014,689 (307)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Investigación y Educación en Enfermería, 2007 Objetivo: Este artículo pretende aportar al debate sobre la participación pública y privada en la provisión de servicios de salud y discutir los aspectos principales de las reformas de salud en Colombia en el contexto internacional y algunos de sus ...
Gloria Molina M +1 more
doaj
“Dream” and Poverty Alleviation
Mimbar, 2017 This research is motivated by the failure of Indonesian government in implementing its poverty alleviation. Poverty rate in Indonesia does not decrease although the government has implemented a complete strategy to address the problem.
Pajar Hatma Indra Jaya
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
State Collapse: Government Failure in Gaddafi's Libya
PopulikaThis article discusses the background and conditions of Libya before and during the reign of Muammar al-Gaddafi, which ended with the fall of his regime in 2011. Libya has a strong economy thanks to its oil resources, but Gaddafi's rule was characterized
Carelia Pradita Putri Hariyanti +2 more
doaj +1 more source
Do Donor Restrictions Affect Sustainability of Water and Sanitation Interventions? Results from a Pilot Survey [PDF]
, 2015 The Water, Sanitation and Hygiene (WASH) sector has had its challenges. Reasons for failure usually focus on technology, water users, community management committees, local government, national government policies and implementers (NGOs).
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Jurnal Presipitasi, 2019 During the dry season there was a scarcity of the availability of clean water in several Central Java province (Wonogiri, Sukoharjo, Karanganyar Disrict and Surakarta City), including Wosusokas Regional Region, so the government often drops clean water ...
Kartika Hapsari Sutantiningrum +1 more
doaj +1 more source
The Case for an Orderly Resolution Regime for Systemically-Important Financial Institutions [PDF]
, 2009 Outlines the need to give the government authority to resolve a financial institution if its failure poses serious systemic risks, examines concerns and counterproposals, and offers recommendations and considerations for designing such a ...
H. Rodgin Cohen, Morris Goldstein
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source