Results 51 to 60 of about 234,711 (258)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
State Collapse: Government Failure in Gaddafi's Libya
PopulikaThis article discusses the background and conditions of Libya before and during the reign of Muammar al-Gaddafi, which ended with the fall of his regime in 2011. Libya has a strong economy thanks to its oil resources, but Gaddafi's rule was characterized
Carelia Pradita Putri Hariyanti +2 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Jurnal Presipitasi, 2019 During the dry season there was a scarcity of the availability of clean water in several Central Java province (Wonogiri, Sukoharjo, Karanganyar Disrict and Surakarta City), including Wosusokas Regional Region, so the government often drops clean water ...
Kartika Hapsari Sutantiningrum +1 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Investigación y Educación en Enfermería, 2007 Objetivo: Este artículo pretende aportar al debate sobre la participación pública y privada en la provisión de servicios de salud y discutir los aspectos principales de las reformas de salud en Colombia en el contexto internacional y algunos de sus ...
Gloria Molina M +1 more
doaj
Corporate governance and Corporate Failure
2nd Annual International Conferences on Accounting and Finance (AF 2012), 2012 AbstractThe purpose of this research is to examine the influence of corporate governance characteristics on the corporate failure of listed companies in Sri Lanka. This study utilized publicly available data from annual reports of a sample of 70 failed firms and a sample of matched 70 non failed firms listed on Colombo stock market for a period ...
Lakshan, A.M.I., Wijekoon, W.M.H.N.
openaire +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source