Results 51 to 60 of about 271,411 (302)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

AI in the Government: Responses to Failures

open access: yes, 2022
Artificial Intelligence (AI) is pervading the government and transforming how public services are provided to consumers—from allocation of government benefits to enforcement of the law, monitoring of risks, and provision of services. Despite technological improvements, AI systems are fallible and may err.
Chiara Longoni, Luca Cian, Ellie Kyung
openaire   +1 more source

The impact of critical success factors on government IT projects : a case study of the Defence Information Infrastructure Programme [PDF]

open access: yes, 2014
Government IT mega-projects often end in costly failure, despite attempts to identify those Critical Success Factors (CSFs) that lead to project success.
Maddison, A
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Participación pública y privada en la provisión de servicios de salud, Colombia 2006 Public and private participation in Health Services provision in Colombia 2006

open access: yesInvestigación y Educación en Enfermería, 2007
Objetivo: Este artículo pretende aportar al debate sobre la participación pública y privada en la provisión de servicios de salud y discutir los aspectos principales de las reformas de salud en Colombia en el contexto internacional y algunos de sus ...
Gloria Molina M   +1 more
doaj  

“Dream” and Poverty Alleviation

open access: yesMimbar, 2017
This research is motivated by the failure of Indonesian government in implementing its poverty alleviation. Poverty rate in Indonesia does not decrease although the government has implemented a complete strategy to address the problem.
Pajar Hatma Indra Jaya
doaj   +1 more source

The anatomy of government failure

open access: yes, 2016
Government failure is a much bigger problem than its contemporary treatment implies. Setting aside natural disasters, most of the great catastrophes of human history have been government failures of one sort or another.
Keech, William R., Munger, Michael
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

State Collapse: Government Failure in Gaddafi's Libya

open access: yesPopulika
This article discusses the background and conditions of Libya before and during the reign of Muammar al-Gaddafi, which ended with the fall of his regime in 2011. Libya has a strong economy thanks to its oil resources, but Gaddafi's rule was characterized
Carelia Pradita Putri Hariyanti   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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