Results 41 to 50 of about 4,849,042 (298)
Among Lester Salamon’s early theoretical contributions was the introduction of the “Voluntary Failure” concept. In a series of articles published in the second half of the 1980s (Salamon, L. M. 1987a.
Bassi Andrea
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E-government information systems (IS) projects experience numerous challenges that can lead to total or partial failure. The project failure factors have been identified and studied by numerous researchers, but the root causes of such failures are not ...
Joseph B Nyansiro +2 more
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Book Review: "The Economists' Hour: False Prophets, Free Markets, and the Fracture of Society"
Binyamin Appelbaum's new book, _The Economists' Hour_ argues that nefarious free market economists took over economic policy around 1950, and promotes democratic constraints on markets as a solution.
David Gordon
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Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Readiness of local government in PPP project development - case of LRT Bandung [PDF]
Infrastructure development with PPP (Public Private Partnership) scheme is a relatively new concept applied by the Indonesian construction industry as an alternative to overcome delays and the low absorption of the Indonesian Government Budget (APBN) and
Putri Revana, Wirahadikusumah Reini D.
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MBS taskforce fails the pub test
The nursing profession has been frustrated by a government review body that has ignored evidence-based recommendations resulting in a failure to meet community expectations.
Toni Hains +2 more
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
On the Failure to Reach the Optimal Government Debt Ceiling
We develop a government debt management model to study the optimal debt ceiling when the ability of the government to generate primary surpluses to reduce the debt ratio is limited. We succeed in finding a solution for the optimal debt ceiling.
Abel Cadenillas, Ricardo Huamán-Aguilar
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