Results 41 to 50 of about 271,411 (302)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
On the Failure to Reach the Optimal Government Debt Ceiling
Risks, 2018 We develop a government debt management model to study the optimal debt ceiling when the ability of the government to generate primary surpluses to reduce the debt ratio is limited. We succeed in finding a solution for the optimal debt ceiling.
Abel Cadenillas, Ricardo Huamán-Aguilar
doaj +1 more source
MBS taskforce fails the pub test
Journal of Perioperative Nursing, 2021 The nursing profession has been frustrated by a government review body that has ignored evidence-based recommendations resulting in a failure to meet community expectations.
Toni Hains +2 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Digitally disengaged: government resistance to civic participation [PDF]
, 2013 This paper examines digital engagement through local e-government. Drawing from a local government case study, it suggests that limitations to online civic involvement are often the result of insufficient government reception of, and responses to ...
Julie Freeman, FREEMAN, Julie
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Jurnal Sistem Informasi, 2015 Since Inpres No.3 of 2003 about policies and strategies for e-Government development, the Government institution was required to be able to take advantage of the progress of Information and Communication Technology (ICT) in order to improve the ...
Darmawan Baginda Napitupulu
doaj +3 more sources
Management of Oil Revenues: Has That of Azerbaijan Been Prudent?
Economies, 2017 To help explain the common failure of oil or other natural resource exporting countries to diversify into industry, it has been common to trace this failure to real exchange rate appreciation. This has also been done in Azerbaijan.
Sarvar Gurbanov +2 more
doaj +1 more source