Results 71 to 80 of about 271,411 (302)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Remaking Local Government: Success and Failure Under Indiana’s Government Modernization Act
Journal of Public and Nonprofit Affairs, 2017 During the period of 2008 to 2012, four consolidation attempts occurred under Indiana’s Government Modernization Act: two proposing city–county consolidation and two proposing town–township consolidation.
Charles D. Taylor +2 more
doaj
, 2009 The phenomenon of government failure, defined here as the inability of a government agency or agencies in a given tier of government or in a federal system of multi-tiered governments to intervene optimally in a market economy, is now a familiar area in ...
Dollery, Brian Edward
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Optimal government size and economic growth in France (1871-2008) : An explanation by the State and market failures [PDF]
This paper analyses the effect of public expenditure on economic growth from both a theoretical and an empirical point of view. Given that the economic literature supplies numerous and conflicting views on the topic, the article offers a framework ...
Mickaël Melki, François Facchini
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Economic Perspectives on Government
, 2019 This book introduces and applies the economic way of thinking to public policy and public administration. It provides a non-technical introduction and assumes no prior economic or mathematical training but looks closely at the methodological and ...
Dowding, Keith, Taylor, Brad R.
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
, 2013 Politicians and commentators often depict government failure as some sort of modern epidemic burdening society. But equally often the concept of “government failure” remains inadequately defined.
Orbach, Barak
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