Results 61 to 70 of about 3,307,718 (207)
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
The Chinese-Russian Investment Cooperation: Current State, Problems and Development Prospects
Vestnik RUDN. International Relations, 2010 In process of growth of investments of the Chinese enterprises to Russia variety of problems has gradually come to light. Sometimes there were simply failures to an investment of financial assets.
- Wang Yuesheng, - Yang Li, A Y Seleckis
doaj
OPERATION PHAKISA: REFLECTIONS UPON AN AMBITIOUS MARITIME-LED GOVERNMENT INITIATIVE
Scientia Militaria, 2020 Operation Phakisa enjoys ‘presidential’ status as a project launched by and housed within the Presidency of the Republic of South Africa during the Zuma administration.
Vreÿ, Francois
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Explaining bank failures: deposit insurance, regulation, and efficiency [PDF]
This paper uses micro-level historical data to examine the causes of bank failure. For state charactered Kansas banks during 19 10-28, time-to-failure is explicitly modeled using a proportional hazards framework. In addition to standard financial ratios,
David C. Wheelock, Paul W. Wilson
core
Desafíos, 2010 This article is based on research carried out in three municipalities of the Catatumbo (North Santander department, Colombia) region, and analyzes institutional arrangement dysfunctions that arise from active illegal armed groups and illicit crops ...
Miguel Serrano López
doaj
False failures, real distrust: the impact of an infrastructure failure deepfake on government trust
Frontiers in PsychologyDeepfakes today represent a novel threat that can induce widespread distrust more effectively than traditional disinformation due to its potential for greater susceptibility.
Saifuddin Ahmed +3 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Government intervention in education in Turkey: Market and government failures [PDF]
Externalities and equity are the two major arguments failures that provide justification for government intervention in education. Supporters belive that the intervention will correct these failures.
Çokgezen, Murat
core