Results 81 to 90 of about 3,307,718 (207)

Bank failures, financial restrictions, and aggregate fluctuations: Canada and the United States, 1870-1913 [PDF]

open access: yes
During 1870_1913, Canada had a well-diversified branch banking system while banks in the U.S. unit-banking system were less diversified. Canadian banks could issue large-denomination notes with no restrictions on their backing, while all U.S.
Stephen D. Williamson
core  

Metadata on Saudi government websites

open access: yesCybrarians Journal, 2009
Practical study aims to analyse and Descriptors data in a sample of the Saudi government sites. Using Metachecker.net analysis, it has been selected (4) sites are government ministries Saudi Arabia: Ministry of Education, Ministry of Water and ...
Noura Al Hazzani
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Book Review [Understanding] Democracy: An Introduction to Public Choice [PDF]

open access: yesپژوهش‌نامۀ انتقادی متون و برنامه‌های علوم انسانی, 2018
The Public Choice School in Economics can be considered as the application of economic analysis in the field of politics, which is just recently opening its way to the country's academic circles.
Hadi Amiri, Vaheed Moghadam
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Northern Territory Government Photographer

open access: yes, 1983
Aboriginal School, outstation, Yirrkala.Willshire ...

core  

Government Roles and Public Investment Strategies in Economic Development [PDF]

open access: yesSHS Web of Conferences
This study examines the evolution of government participation in the economy, analyzing key theoretical approaches and strategic directions of public investment.
Beisengaliyev Berik   +1 more
doaj   +1 more source

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