Results 111 to 120 of about 306,287 (257)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Impact of demographic, environmental, socioeconomic, and government intervention on the spreading of COVID-19. [PDF]

Clin Epidemiol Glob Health, 2021
Mashrur FR, Roy AD, Chhoan AP, Sarker S, Saha A, Hasan SMN, Saha S.   +6 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Does Government Intervention Ensure Food Safety? Evidence from China. [PDF]

Int J Environ Res Public Health, 2021
Zhang H, Sun C, Huang L, Si H.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Gender and LPG use after government intervention in rural north India. [PDF]

World Dev, 2021
Vyas S, Gupta A, Khalid N.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

DEVLETİN REGÜLASYONLAR YOLUYLA PİYASALARA MÜDAHALESİ ve TÜRKİYE ENERJİ PİYASALARI

Sosyal Ekonomik Araştırmalar Dergisi, 2009
İktisat politikasının temel amacı, optimal kaynak tahsisini sağlamak ve toplum refahını maksimize etmektir. Ancak piyasa mekanizması her durumda sosyal faydanın maksimize edilmesini sağlayamaz ve devlet müdahalesine ihtiyaç gösterir.
Burcu Güvenek
doaj   +2 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Government intervention and bank markups: Lessons from the global financial crisis for the COVID-19 crisis. [PDF]

J Bank Financ, 2021
Tan B, Igan D, Martinez Peria MS, Pierri N, Presbitero AF.   +4 more
europepmc   +1 more source