Results 71 to 80 of about 1,588,921 (305)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Tripartite Evolutionary Game Theory Approach for Low-Carbon Power Grid Technology Cooperation With Government Intervention

IEEE Access, 2020
Low-carbon technology innovation of power grid is vital for grid enterprises to improve their competitiveness and resource utilization efficiency. In this paper, a novel tripartite evolutionary game theory is proposed to examine the behavioral strategies
Xin Zhao, Yu Bai, Lili Ding, Lei Wang
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Industrial development in developing countries and the role of government interventions

PSL Quarterly Review, 2013
The work argues that while export orientation (in the sense of providing neutral incentives between foreign and domestic markets) is desirable, the experience of successful industrialisers does not support the minimalist government role prescribed.
S. LALL, G. KELL
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Forest fires: Evaluation of government intervention measures [PDF]

The purpose of this paper is to examine the relation between government measures, volunteer participation, climate variables and forest fires. A number of studies have related forest fires to causes of ignition, to fire history in one area, to the type ...
Clara Riba, Xavier Ballart
core  

Lessons learnt from the broadband diffusion in South Korea and the UK: Implications for future government intervention in technology diffusion [PDF]

, 2006
Governments around the globe are rapidly introducing e-government initiatives with the role of the internet being regarded as pertinent. Information and Communication Technologies (ICTs) offer the capacity to an improved internet. Broadband technology is
Choudrie, J, Papazafeiropoulou, A
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Impact of the digital economy on low carbon sustainability evidence from the Yellow River Basin

Frontiers in Energy Research
As the digital economy increasingly dominates a substantial portion of the national economy, comprehending its role in promoting sustainable development has become an imperative research question—particularly in the context of the Yellow River Basin ...
Gaofei Wang, Qingwen Yuan, Yong Jiao
doaj   +1 more source

Government Intervention as an Optimal Response to Government (not Market!) Failure [PDF]

This paper provides a theory of government intervention, such as government ownership, regulation, mandatory public schooling, subsidies, and industrial policy, as an optimal policy response due to the inability to commit not to expropriate private ...
Adriano Rampini, Alberto Bisin
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