Results 81 to 90 of about 5,133,723 (284)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Government and Health Outcomes [PDF]

open access: yes
In this paper, I summarize the results of empirical studies in the areas of schooling and health, public programs and infant mortality, and government regulation of teenage smoking. My review is selective and is based on my own research.
Michael Grossman
core  

Fiscal Year 2010 U.S. Government Financial Statements: Federal Government Continues to Face Financial Management and Long-Term Fiscal Challenges [PDF]

open access: yes, 2011
Testimony issued by the Government Accountability Office with an abstract that begins "GAO annually audits the consolidated financial statements of the U.S. government.
United States. Government Accountability Office.
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

CHINA'S GOVERNMENT PROGRAMS SUPPORTING ELECTRIC VEHICLE PRODUCTION: IMPACT ON SECTOR DEVELOPMENT AND GLOBAL TRENDS IN SUSTAINABLE TRANSPORTATION

open access: yesGreen, Blue and Digital Economy Journal
The purpose of this article is to substantiate the necessity of government programs in the People's Republic of China (PRC) in supporting electric vehicle (EV) production, analyze the impact of these initiatives on the growth and development of the EV ...
Oleksii Honcharov
doaj   +1 more source

Federal Education Funding: Overview of K-12 and Early Childhood Education Programs [PDF]

open access: yes, 2010
A letter report issued by the Government Accountability Office with an abstract that begins "The federal government invests in the education of children, in part, to help ensure that the United States has a well-educated and skilled workforce to compete ...
United States. Government Accountability Office.
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Government Programs Focused on Financial Support for SMEs (2014-2018) [PDF]

open access: yesOvidius University Annals: Economic Sciences Series, 2019
The SMEs or the Small and medium-sized enterprises sector is underlying the Romanian economy, its share representing 99.64% of the total enterprises. As the main driver of economic growth, SMEs are facing several problems, which generate a direct impact ...
Nicoleta Asaloș, Ionel Bostan
doaj  

State Youth Policy: Peculiarities of Implementation and Reflection in the State Programs of the Russian Federation and Moscow City

open access: yesУправление, 2017
The article considers the essence of the state youth policy and the directions of its implementation at the level of the Russian Federation and Moscow city. The analysis of government programs is made from a position of reflection in them of youth policy
O. N. Lyubina
doaj   +1 more source

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