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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Nursing Management (Springhouse), 1993 Strategic planning identifies a department's environmental factors while establishing its purpose, mission, philosophy and goals and developing a long-range plan and objectives. This hospital's practical approach mirrors the nursing process related to assessment, diagnosis and planning, implementation and evaluation.
openaire +5 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
SSM - Mental HealthBackground: The province of Khyber Pakhtunkhwa (KP) in Pakistan faces significant gaps in mental health services, marked by limited resources and inequitable distribution of services. To strengthen the existing services in nine districts of the province,
Asma Humayun +2 more
doaj +1 more source
Annual Conference of the International Group for Lean ConstructionReports on the use of takt tend to focus on applications aimed at so-called operational takt planning. Instead, this paper focuses on strategic takt planning. Strategic- and operational takt planning must go hand in hand. Specifically, strategic takt planning is required upfront in project delivery as it informs prospective contractors what is expected
Tommelein, ID, Emdanat, S
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
The demand for military spending in Latin American countries
Latin American Economic Review, 2018 The allocation of resources to defence and national security is influenced by several factors, both domestic and external. Empirical findings suggest that military spending is determined by economic, strategic, political, and security factors.
Christos Kollias +3 more
doaj +1 more source