Results 1 to 10 of about 19,806 (216)

Diagnostic Value of cfDNA in Pancreatic Cancer

open access: yesZhongliu Fangzhi Yanjiu, 2022
Objective To explore the diagnostic value of cfDNA in pancreatic cancer. Methods A total of 467 patients with pancreatic cancer and 129 healthy controls were enrolled. cfDNA concentration was detected using the QuantiDNA Direct cfDNA Test (DiaCarta) kit.
XU Yijun, ZHU Mingchen
doaj   +1 more source

Adoption of a non-invasive prenatal test (NIPT) in prenatal screening in Moscow: first results

open access: yesRussian Open Medical Journal, 2021
The objective — To assess the effectiveness of including NIPT in the structure of prenatal diagnostics in Moscow. Material and Methods — Totally 5,181 pregnancies undergoing screening for fetal trisomy using NIPT during the period from 01.04.2020 to 30 ...
Anton S. Olenev   +7 more
doaj   +1 more source

Cell-free DNA methylome profiling by MBD-seq with ultra-low input

open access: yesEpigenetics, 2022
Methylation signatures in cell-free DNA (cfDNA) have shown great sensitivity and specificity in the characterization of tumour status and classification of tumour types, as well as the response to therapy and recurrence. Currently, most cfDNA methylation
Jinyong Huang   +2 more
doaj   +1 more source

Dynamics of methylated cell-free DNA in the urine of non-small cell lung cancer patients

open access: yesEpigenetics, 2022
High levels of methylated DNA in urine represent an emerging biomarker for non-small cell lung cancer (NSCLC) detection and are the subject of ongoing research.
Sander Bach   +7 more
doaj   +1 more source

Benefits of Plasma Over Other Body Fluids for Circulating Tumor DNA Detection in Genitourinary Tumors

open access: yesSociété Internationale d’Urologie Journal, 2023
None.
Manishkumar S. Patel, Liang Wang
doaj   +1 more source

cfDNA in pancreatic neuroendocrine carcinoma management with Cushing’s syndrome

open access: yesEndocrine Oncology, 2023
We report a case of metastatic pancreatic neuroendocrine carcinoma associated with paraneoplastic Cushing’s syndrome, successively treated with five lines of treatment (platin-etoposide, LV5FU2-dacarbazine, FOLFIRINOX, pembrolizumab, and paclitaxel) and ...
Laura Gerard   +11 more
doaj   +1 more source

Immunoaging – the effect of age on serum levels of NET biomarkers in men: a pilot study

open access: yesInternational Journal of Occupational Medicine and Environmental Health, 2023
Objectives The study aimed to evaluate the impact of aging on the formation of neutrophil extracellular traps (NETs). The impaired formation of NETs is the cause of an abnormal innate immune response.
Marzena Garley   +6 more
doaj   +1 more source

Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology

open access: yeseLife, 2021
We developed genetic-epigenetic tissue mapping (GETMap) to determine the tissue composition of plasma DNA carrying genetic variants not present in the constitutional genome through comparing their methylation profiles with relevant tissues.
Wanxia Gai   +18 more
doaj   +1 more source

Ultrashort ssDNA in Retinoblastoma Patients Blood Plasma Detected by a Novel High Resolution HPCL Technique: a Preliminary Report

open access: yesActa Medica, 2020
A significant population of ultrashort (50–150n) single-stranded DNA fragments were found in exosome-free blood plasma of retinoblastoma patients (6.84 ng mL−1), but not in plasma of healthy donors.
Kirill V. Ermakov   +5 more
doaj   +1 more source

Association between Levels of Total Cell-Free DNA and Development of Preeclampsia—A Literature Review

open access: yesAmerican Journal of Perinatology Reports, 2021
Objectives The aim of the study is to synthesize the evidence and evaluate the total cell-free deoxyribonucleic (cfDNA) associated with the prediction of preeclampsia (PE). Total cfDNA is constituted by both cell-free fetal DNA (cffDNA) originated mainly
Yi Wu   +5 more
doaj   +1 more source

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