Results 1 to 10 of about 23,420 (253)

Advances in cfDNA research for pregnancy-related diseases

Frontiers in Cell and Developmental Biology
Circulating cell-free DNA (cfDNA) comprises extracellular DNA fragments released into bodily fluids through cellular processes such as apoptosis, necrosis, and active secretion. Alterations in cfDNA concentration, fragmentation patterns, and molecular characteristics under physiological and pathological conditions, including pregnancy-related disorders,
Yimei Meng, Yimei Meng, Yu Yan, Xiaoshan Yue, Yan Li, Yanxiang Mo   +5 more
openaire   +3 more sources

AGE-ASSOCIATED VARIABILITY OF CIRCULATING FREE DNA CHARACTERISTICS: GENOME-WIDE ANALYSIS

Journal of Bioinformatics and Genomics
The fragments of circulating free DNA (cfDNA) found in plasma are formed due to the genomic DNA degradation during cellular death. The present study is the first research of age-associated variability of cfDNA characteristics performed on the group of ...
Meshkov I.O., Remizova J.A., Makarova A.S., Primova A.A., Petrova V.A., Bukhanova A.A., Kumar N.A., Ivashechkin A.A., Makhotenko A.V., Snigir E.A., Makarov V.V., Yudin V.S., Keskinov A.A., Yudin S.M.   +13 more
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Fragmentation patterns of pathogen-derived cell-free DNA as a promising non-invasive biomarker for bloodstream infection diagnosis

Practical Laboratory Medicine
Background: Bloodstream infections (BSIs) caused by bacteria, viruses, and parasites pose a global health challenge, with high mortality rates. Traditional blood cultures are considered the gold standard but are limited by long turnaround times, low ...
Qichuan Fu, Jie Wang, Liya Yue, Tianyu Lu, Wenyu Shi, Cuidan Li, Xiaoyuan Jiang, Peihan Wang, Fei Chen   +8 more
doaj   +1 more source

cfDNA monitoring is feasible in SCLC [PDF]

Nature Reviews Clinical Oncology, 2019
openaire   +2 more sources

Cell-free DNA: a metabolic byproduct with diagnostic and prognostic potential in rheumatic disorders

Frontiers in Pharmacology
The release of intracellular DNA into the extracellular area occurs via two pathways: cell death and active secretion by cells. The DNA, which is free in the extracellular space, is commonly known as Cell-Free DNA (cfDNA).
Fancheng Liu, Fancheng Liu, Yazhen Su, Yazhen Su, Xinling Liu, Li Zhao, Li Zhao, Zewen Wu, Zewen Wu, Yang Liu, Yang Liu, Liyun Zhang, Liyun Zhang   +12 more
doaj   +1 more source

CfDNA Mutation [PDF]

, 2020
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Cell-free DNA profiles of dermatomyositis and its potential role in discriminating phenotypes

Frontiers in Immunology
BackgroundCell-free DNA (cfDNA) functions in the early-detection and monitoring of autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis.
Zhuang-li Tang, Peng-yu Chen, Heng Zhang, Hua-li Cao, Ru Dai, Yu-chen Lou, Yan-hong Sun, Yuan Zhou, Xue-yan Chen, Mei-jie Zhang, Ya-qi Wang, Xiao-yong Man   +11 more
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cfDNA analysis from blood in melanoma.

Annals of translational medicine, 2015
Testing of tumor tissue remains the recommended method for detecting the presence of somatic mutations in human malignancies. V600E is the most frequent somatic point mutation in metastatic melanoma, providing a unique molecular marker for this malignancy.
Miguel A, Molina-Vila, Clara Mayo, de-Las-Casas, Jordi, Bertran-Alamillo, Nuria, Jordana-Ariza, María, González-Cao, Rafael, Rosell   +5 more
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cfDNA As A Metabolic Marker

Medicine & Science in Sports & Exercise, 2019
David Ochmann, Charlotte Kreuz, Silvia Wenzel, Perikles Simon   +3 more
openaire   +2 more sources

Diagnostic performance of donor-derived cell-free DNA for acute rejection in kidney allograft biopsies. [PDF]

J Bras Nefrol
Nakamura MR, Foresto RD, Gomes VRDS, Proença HM, Requião-Moura L, Medina-Pestana J, Tedesco-Silva H.   +6 more
europepmc   +1 more source