Results 11 to 20 of about 23,420 (253)
Microfluidic Technologies for cfDNA Isolation and Analysis [PDF]
Micromachines, 2019 Cell-free DNA (cfDNA), which promotes precision oncology, has received extensive concern because of its abilities to inform genomic mutations, tumor burden and drug resistance. The absolute quantification of cfDNA concentration has been proved as an independent prognostic biomarker of overall survival.
Yi Qiao, Jing Tu, Qiao Yi
exaly +5 more sources
Exploration of cfDNA landscape in NIPT and clinical utilities of cfDNA based gene expression inference in prenatal diagnostics [PDF]
Frontiers in GeneticsCell-free DNA (cfDNA) is a dynamic biomarker reflecting the physiological state of the body. Its unique physical and biochemical properties, inherited from the tissue of origin, enable a wide range of clinical applications. From methylation patterns and fragmentation profiles to genetic variants, cfDNA holds immense potential for diagnosing and ...
Jianjiang Zhu, Yang Du, Hong Qi
exaly +5 more sources
Performance of prenatal cfDNA screening for sex chromosomes [PDF]
Genetics in Medicine, 2023 The aim of this study was to assess the performance of cell-free DNA (cfDNA) screening to detect sex chromosome aneuploidies (SCAs) in an unselected obstetrical population with genetic confirmation.This was a planned secondary analysis of the multicenter, prospective SNP-based Microdeletion and Aneuploidy RegisTry (SMART) study.
Kimberly Martin +22 more
core +6 more sources
Fragmentomic cfDNA Patterns in Noninvasive Prenatal Testing and Beyond
Journal of Biomedicine and Translational Research, 2021 The release of fetoplacental cell-free DNA (cfDNA) into the maternal bloodstream opened up new avenues towards noninvasive prenatal testing (NIPT) for aneuploidies, hereditary DNA mutations and other pregnancy-related developmental disorders ...
Kavish Kohabir +2 more
doaj +3 more sources
Scientific ReportsEarly detection plays a critical role in reducing lung cancer mortality. DNA methylation biomarker assay based on cell-free DNA (cfDNA) is a promising method for early detection of lung cancer. In this study, we aimed to develop a prediction model based on cfDNA methylation biomarkers and cfDNA concentration for early detection of lung cancer.
Ke, Li +6 more
openaire +4 more sources
Plasma cfDNA predictors of established bacteraemic infection
Access Microbiology, 2022 Introduction. Increased plasma cell-free DNA (cfDNA) has been reported for various diseases in which cell death and tissue/organ damage contribute to pathogenesis, including sepsis. Gap Statement. While several studies report a rise in plasma cfDNA in bacteraemia and sepsis, the main source of cfDNA ...
Nadia Urosevic +2 more
exaly +3 more sources
The Nexus of cfDNA and Nuclease Biology [PDF]
Trends in Genetics, 2021 Cell-free DNA (cfDNA) is a widely used noninvasive biomarker for diagnosis and prognosis of multiple disease states. Emerging evidence suggests that cfDNA might not just be passive waste products of cell death but could have a physiological and pathological function in inflammation and autoimmunity.
Diana S.C. Han, Y.M. Dennis Lo
openaire +2 more sources
Société Internationale d’Urologie Journal, 2023 None.
Manishkumar S. Patel, Liang Wang
doaj +1 more source
cfDNA in pancreatic neuroendocrine carcinoma management with Cushing’s syndrome
Endocrine Oncology, 2023 We report a case of metastatic pancreatic neuroendocrine carcinoma associated with paraneoplastic Cushing’s syndrome, successively treated with five lines of treatment (platin-etoposide, LV5FU2-dacarbazine, FOLFIRINOX, pembrolizumab, and paclitaxel) and ...
Laura Gerard +11 more
doaj +1 more source
Hypertensive disorders of pregnancy share common cfDNA methylation profiles. [PDF]
, 2021 Hypertensive disorders of pregnancy (HDP) contribute substantially to perinatal morbidity and mortality. Epigenetic changes point towards cardio-metabolic dysregulation for these vascular disorders.
Zdanowicz, Jarmila A +15 more
core +1 more source