Detection of activating estrogen receptor gene (ESR1) mutations in single circulating tumor cells [PDF]
, 2017 Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our purpose was to demonstrate feasibility to detect and monitor estrogen receptor 1 (ESR1) gene mutations at the single circulating tumor cell (CTC) level in ...
Austin, Laura +9 more
core +3 more sources
Genome-wide study of the effect of blood collection tubes on the cell-free DNA methylome
Epigenetics, 2021 The methylation pattern of cfDNA, isolated from liquid biopsies, is gaining substantial interest for diagnosis and monitoring of diseases. We have evaluated the impact of type of blood collection tube and time delay between blood draw and plasma ...
Ruben Van Paemel +7 more
doaj +1 more source
Maternal cell-free DNA-based screening for fetal microdeletion and the importance of careful diagnostic follow-up. [PDF]
, 2015 BackgroundNoninvasive prenatal screening (NIPS) by next-generation sequencing of cell-free DNA (cfDNA) in maternal plasma is used to screen for common aneuploidies such as trisomy 21 in high risk pregnancies.
Chu, Tianjiao +5 more
core +2 more sources
Endogenous cell-free DNA in fetal bovine serum introduces artifacts to in vitro cell-free DNA models
BioTechniques, 2022 Cell-free DNA (cfDNA) is of growing clinical and research significance. In vitro cfDNA models are a useful tool in cfDNA research; however, artifacts in these models may have implications for the interpretation of new and published data.
Bonnita Werner +2 more
doaj +1 more source
Nucleosomes and neutrophil extracellular traps in septic and burn patients [PDF]
, 2017 NETosis is a host defense mechanism associated with inflammation and tissue damage. Experimental models show that platelets and von Willebrand factor (VWF) are key elements for intravascular NETosis. We determined NETosis in septic and burn patients at 1
Carestia, Agostina +8 more
core +1 more source
The clinical value of serum sST2 and cfDNA in guiding evidence-based nursing care for children with severe pneumonia complicated by myocardial damage [PDF]
Journal of Medical BiochemistryBackground: To investigate how serum sST2 and cfDNA can be used to inform evidence-based nursing practices for children with severe pneumonia and myocardial damage.
Du Meng +5 more
doaj +1 more source
The clinical and prognostic use of circulating tumour cells in breast cancer [PDF]
, 2011 Adjuvant therapies such as endocrine or cytotoxic chemotherapy have been demonstrated to improve overall survival in early breast cancer patients.
Payne, Rachel, Payne, Rachel
core +1 more source
Cell-free DNA in sports medicine: implications for clinical laboratory medicine
Journal of Laboratory Medicine, 2022 Physical activity can have a strong impact on the concentration of several promising candidate biomarkers, including cell-free DNA (cfDNA).
Neuberger Elmo W.I., Simon Perikles
doaj +1 more source
Research in Pharmaceutical SciencesBackground and purpose: Breast cancer is a major global concern, especially because of high mortality linked to advanced stages. Metastasis may occur early, but current diagnostics struggle to detect small metastatic cells.
Zohreh Salimi +3 more
doaj +1 more source
Frontiers in Genetics, 2023 In allograft monitoring of solid organ transplant recipients, liquid biopsy has emerged as a novel approach using quantification of donor-derived cell-free DNA (dd-cfDNA) in plasma.
Nicholas Kueng +10 more
doaj +1 more source