Results 41 to 50 of about 19,806 (216)

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Application of liquid biopsy in lung cancer management

Indian Journal of Pathology and Microbiology
Current advances in the understanding of the lung cancer landscape have drastically changed the approach to treating a patient with lung carcinoma. The field has progressed from analyzing single gene to using advanced techniques like next-generation ...
Shraddhanjali Satapathy, Balamurugan Thirunavukkarasu, Deepali Jain   +2 more
doaj   +1 more source

The significance of serum sST2 and cfDNA in children with severe pneumonia complicated by myocardial damage [PDF]

Journal of Medical Biochemistry
Background: The paper aimed to explore the significance of serum soluble ST2 (sST2) and circulating cell-free DNA (cfDNA) in predicting cardiac functions in children with severe pneumonia complicated by myocardial damage.
Zhao Tingting, Liu Ye, Jia Haoran, Wang Dexing, Du Meng, Wang Weiwei   +5 more
doaj   +1 more source

Clinical relevance of cell-free DNA quantification and qualification during the first month after lung transplantation

Frontiers in Immunology, 2023
BackgroundMany studies have reported the relevance of donor-derived cfDNA (dd-cfDNA) after lung transplantation (LTx) to diagnose and monitor acute rejection (AR) or chronic rejection or infection (INF).
Pascal Pedini, Pascal Pedini, Benjamin Coiffard, Nicem Cherouat, Sylvia Casas, Frédéric Fina, Audrey Boutonnet, Jean Baptiste Baudey, Printil Aho, Agnes Basire, Sophie Simon, Coralie Frassati, Jacques Chiaroni, Jacques Chiaroni, Martine Reynaud-Gaubert, Christophe Picard, Christophe Picard   +16 more
doaj   +1 more source

Combinatorial Power of cfDNA, CTCs and EVs in Oncology

Diagnostics, 2022
Liquid biopsy is a promising technique for clinical management of oncological patients. The diversity of analytes circulating in the blood useable for liquid biopsy testing is enormous. Circulating tumor cells (CTCs), cell-free DNA (cfDNA) and extracellular vesicles (EVs), as well as blood cells and other soluble components in the plasma, were shown as
Corinna Keup, Rainer Kimmig, Sabine Kasimir-Bauer   +2 more
openaire   +5 more sources

Relationship between plasma circulating cell-free DNA concentration and treatment outcomes including prognosis in patients with advanced non-small cell lung cancer

BMC Pulmonary Medicine, 2023
Background Some research found that elevated plasma cell-free DNA (cfDNA) concentrations and poor prognosis are associated in non-small cell lung cancer (NSCLC). However, more studies need to be carried out to verify this conclusion.
Wei-Wei Peng, Ying Liu, Huan-Huan Sha, Shao-Di Wen, Ying Fang, Guo-Ren Zhou   +5 more
doaj   +1 more source

Plasma cfDNA for the Diagnosis and Prognosis of Colorectal Cancer

Journal of Oncology, 2022
Objective. To evaluate the value of cell-free DNA (cfDNA) for the diagnosis and prognosis of colorectal cancer (CRC). Methods. Peripheral blood specimens of 120 CRC patients and 90 healthy volunteers (as a control cohort) were extracted. A quantitative real-time polymerase chain reaction (qRT-PCR) was performed to determine the cfDNA expression ...
Zhiwei Wu, Lijiang Yu, Juan Hou, Lihua Cui, Yufeng Huang, Qing Chen, Yan Sun, Wangkun Lu, Chenggong Zhang, Di Sun   +9 more
openaire   +2 more sources

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source