Results 51 to 60 of about 19,806 (216)

Kinetics of plasma cfDNA predicts clinical response in non-small cell lung cancer patients

Scientific Reports, 2021
Tyrosine kinase inhibitors (TKIs), VEGF/VEGF receptor inhibitors (VEGFIs) and immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced cancers including non-small-cell lung cancer (NSCLC).
Xiaorong Zhou, Chenchen Li, Zhao Zhang, Daniel Y. Li, Jinwei Du, Ping Ding, Haiyan Meng, Hui Xu, Ronglei Li, Effie Ho, Aiguo Zhang, Paul Okunieff, Jianwei Lu, Michael Y. Sha   +13 more
doaj   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

A prediction model based on cfDNA concentration and cfDNA methylation biomarkers for lung cancer detection

Scientific Reports
Early detection plays a critical role in reducing lung cancer mortality. DNA methylation biomarker assay based on cell-free DNA (cfDNA) is a promising method for early detection of lung cancer. In this study, we aimed to develop a prediction model based on cfDNA methylation biomarkers and cfDNA concentration for early detection of lung cancer.
Ke, Li, Huang, Xiang, Liu, Wenting, Hong, Bo, Wang, Hongzhi, Qi, Jian, Chu, Yannan   +6 more
openaire   +3 more sources

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

Implementation of clinical metagenomics for pathogen identification in intra-abdominal sepsis: A case report

Журнал инфектологии
Clinical metagenomics methods significantly expand diagnostic capabilities, especially in cases where pathogens cannot be identified using traditional methods.
V. V. Gostev, S. A. Shlyapnikov, E. V. Baziian, G. A. Pichugina, L. I. Gelezova, O. S. Kalinogorskaya, A. A. Igolkina, V. Yu. Pleshkov, I. A. Tsvetkova, O. V. Goleva, V. A. Ageevets, N. R. Naser, S. V. Sidorenko   +12 more
doaj   +1 more source

The clinical value of serum sST2 and cfDNA in guiding evidence-based nursing care for children with severe pneumonia complicated by myocardial damage [PDF]

Journal of Medical Biochemistry
Background: To investigate how serum sST2 and cfDNA can be used to inform evidence-based nursing practices for children with severe pneumonia and myocardial damage.
Du Meng, Jia Haoran, Zhao Tingting, Liu Ye, Wang Dexing, Wang Weiwei   +5 more
doaj   +1 more source

Quantitative characterization of tumor cell-free DNA shortening

BMC Genomics, 2020
Background Previous studies found that cell-free DNA (cfDNA) generated from tumors was shorter than that from healthy cells, and selecting short cfDNA could enrich for tumor cfDNA and improve its usage in early cancer diagnosis and treatment monitoring ...
Juntang Guo, Kefeng Ma, Hua Bao, Xiangyuan Ma, Yang Xu, Xue Wu, Yang W. Shao, Mei Jiang, Jin Huang   +8 more
doaj   +1 more source

The Role of Multicancer Early Detection Tests in Head and Neck Squamous Cell Carcinoma: A Case Series

Head &Neck, EarlyView.
ABSTRACT Background Head and neck squamous cell carcinoma (HNSCC) lacks an established screening program, and most cases are diagnosed at advanced stages. Multi‐cancer early detection (MCED) blood‐based assays represent a promising approach, yet real‐world clinical experience with MCED‐identified HNSCC remains limited.
Abhinav Talwar, Olivia Ben‐Levy, Nikhil Sriram, Sandeep Samant   +3 more
wiley   +1 more source

Non-invasive chromosome screening of embryos fertilized in vitro: A single center, retrospective study

Asian Pacific Journal of Reproduction
Objective: To evaluate the center’s experience with non-invasive preimplantation genetic testing for aneuploidy (NIPGT-A), focusing on embryo aneuploidy assessment, euploidy-linked pregnancy outcomes, and the relationship between embryo morphology and ...
K Gayathri, R Manipriya
doaj   +1 more source

cfDNA-Based NGS IG Analysis in Lymphoma

, 2022
AbstractLiquid biopsy is a novel diagnostic approach at first developed to characterize the molecular profile of solid tumors by analyzing body fluids. For cancer patients, it represents a noninvasive way to monitor the status of the solid tumor with respect to representative biomarkers. There is growing interest in the utilization of circulating tumor
Christiane, Pott, Michaela, Kotrova, Nikos, Darzentas, Monika, Brüggemann, Mouhamad, Khouja   +4 more
openaire   +2 more sources