Results 71 to 80 of about 23,420 (253)

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

Advanced Functional Materials, EarlyView.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim, Seong‐Jin Shin, Sak Lee, Nandin Mandakhbayar, Ji‐Hye Kang, Da‐Young Kong, Seong‐Doo Hong, Ueon Sang Shin, Hae‐Won Kim, Jung‐Hwan Lee   +9 more
wiley   +1 more source

Dummy cfDNA samples

, 2022
The archive contains 25 control and 25 cancer dummy sequencing read files (.fq.gz) created by merging multiple real files from healthy controls and lung cancer patients respectively, followed by random downsampling to 100k reads.
Norbert Moldovan (4586956)
core   +1 more source

Clinical relevance of circulating biomarkers in breast cancer metastasis detection: "insights from liquid biopsy technology"

Research in Pharmaceutical Sciences
Background and purpose: Breast cancer is a major global concern, especially because of high mortality linked to advanced stages. Metastasis may occur early, but current diagnostics struggle to detect small metastatic cells.
Zohreh Salimi, Rasoul Fatehifard, Mahmoud Aghaei, Mojtaba Panjehpour   +3 more
doaj   +1 more source

Clinical relevance of cell-free DNA quantification and qualification during the first month after lung transplantation

Frontiers in Immunology, 2023
BackgroundMany studies have reported the relevance of donor-derived cfDNA (dd-cfDNA) after lung transplantation (LTx) to diagnose and monitor acute rejection (AR) or chronic rejection or infection (INF).
Pascal Pedini, Pascal Pedini, Benjamin Coiffard, Nicem Cherouat, Sylvia Casas, Frédéric Fina, Audrey Boutonnet, Jean Baptiste Baudey, Printil Aho, Agnes Basire, Sophie Simon, Coralie Frassati, Jacques Chiaroni, Jacques Chiaroni, Martine Reynaud-Gaubert, Christophe Picard, Christophe Picard   +16 more
doaj   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Kinetics of plasma cfDNA predicts clinical response in non-small cell lung cancer patients

Scientific Reports, 2021
Tyrosine kinase inhibitors (TKIs), VEGF/VEGF receptor inhibitors (VEGFIs) and immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced cancers including non-small-cell lung cancer (NSCLC).
Xiaorong Zhou, Chenchen Li, Zhao Zhang, Daniel Y. Li, Jinwei Du, Ping Ding, Haiyan Meng, Hui Xu, Ronglei Li, Effie Ho, Aiguo Zhang, Paul Okunieff, Jianwei Lu, Michael Y. Sha   +13 more
doaj   +1 more source

Levels of Cell-Free DNA in Kidney Failure Patients before and after Renal Transplantation

Cells, 2023
Circulating cell-free DNA (cfDNA) has diverse applications in oncological, prenatal, toxicological, cardiovascular, and autoimmune diseases, diagnostics, and organ transplantation.
Chiara Leotta, Leah Hernandez, Lubomira Tothova, Samsul Arefin, Paola Ciceri, Mario Gennaro Cozzolino, Peter Barany, Milan Chromek, Peter Stenvinkel, Karolina Kublickiene   +9 more
doaj   +1 more source

The Role of Multicancer Early Detection Tests in Head and Neck Squamous Cell Carcinoma: A Case Series

Head &Neck, EarlyView.
ABSTRACT Background Head and neck squamous cell carcinoma (HNSCC) lacks an established screening program, and most cases are diagnosed at advanced stages. Multi‐cancer early detection (MCED) blood‐based assays represent a promising approach, yet real‐world clinical experience with MCED‐identified HNSCC remains limited.
Abhinav Talwar, Olivia Ben‐Levy, Nikhil Sriram, Sandeep Samant   +3 more
wiley   +1 more source

The clinical value of serum sST2 and cfDNA in guiding evidence-based nursing care for children with severe pneumonia complicated by myocardial damage [PDF]

Journal of Medical Biochemistry
Background: To investigate how serum sST2 and cfDNA can be used to inform evidence-based nursing practices for children with severe pneumonia and myocardial damage.
Du Meng, Jia Haoran, Zhao Tingting, Liu Ye, Wang Dexing, Wang Weiwei   +5 more
doaj   +1 more source

Quantitative characterization of tumor cell-free DNA shortening

BMC Genomics, 2020
Background Previous studies found that cell-free DNA (cfDNA) generated from tumors was shorter than that from healthy cells, and selecting short cfDNA could enrich for tumor cfDNA and improve its usage in early cancer diagnosis and treatment monitoring ...
Juntang Guo, Kefeng Ma, Hua Bao, Xiangyuan Ma, Yang Xu, Xue Wu, Yang W. Shao, Mei Jiang, Jin Huang   +8 more
doaj   +1 more source