Results 91 to 100 of about 29,683 (253)

Blood‐Based Circulating Tumor DNA Assays for Early Colorectal Cancer Detection: A Systematic Review of Performance in Asymptomatic Screening Populations

International Journal of Cancer, EarlyView.
Early detection of colorectal cancer via population‐based screening programs can reduce incidence and mortality, but current screening approaches are limited. This systematic review evaluated the screening potential of blood‐based circulating tumor DNA assays in asymptomatic screening populations.
Caroline Ledertoug Kahn, Maria Wissing Rasmussen, Jakob Kleif, Inge Søkilde Pedersen, Christina Therkildsen   +4 more
wiley   +1 more source

Beta cell death by cell-free DNA and outcome after clinical islet transplantation [PDF]

, 2018
Background: Optimizing engraftment and early survival after clinical islet transplantation is critical to long-term function, but there are no reliable, quantifiable measures to assess beta cell death.
Campbell, Patricia, Dor, Yuval, Gala Lopez, Boris L., Glaser, Benjamin, Kin, Tatsuya, Malcolm, Andrew J., Neiman, Daniel, O’Gorman, Doug, Pepper, Andrew R., Pianzin, Sheina, Senior, Peter A., Shapiro, A.M. James, Shemer, Ruth   +12 more
core   +2 more sources

Diagnostic urinary cfDNA detected in human cystic echinococcosis

Molecular and Biochemical Parasitology, 2020
Cystic echinococcosis (CE) is a major neglected tropical zoonotic disease caused by the tissue-dwelling larval stage of the cestode parasite Echinococcus granulosus. For individuals suspected of CE, the diagnostic standard is imaging using ultrasonography, X rays, or computed tomography.
Toribio, Luz, Santivañez, Saul, Scott, A.L., Enriquez, Raul, Sedano, Cesar, Soto Becerra, Percy, García Lescano, Héctor Hugo, Shiff, C.J., Cysticercosis Working Group in Peru   +8 more
openaire   +3 more sources

Clinical and Radiometabolic Correlatives of ddPCR Liquid Biopsy for BRAF V600 Mutated Melanoma

International Journal of Cancer, EarlyView.
Commercial circulating tumor DNA (ctDNA) liquid biopsy tests are increasingly used for disease monitoring and surveillance in melanoma. However, data regarding the possible correlations between ctDNA and baseline clinical and radiometabolic parameters such as metastatic locations, tumor volume, and tumor glycolysis in patients with BRAF‐mutated ...
Ronen Stoff, Gokce Belge Bilgin, Yalda Nikanpour, Geoffrey B. Johnson, Benjamin R. Kipp, David M. Zahrieh, Katherine B. Geiersbach, Matthew S. Block, Svetomir N. Markovic   +8 more
wiley   +1 more source

The importance of gene polymorphism in familial inheritance of endometriosis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The study aimed to investigate familial transmission patterns in women with endometriosis by generating a customized single‐nucleotide polymorphism (SNP) array. Methods Patients aged 18–45 who were diagnosed histopathologically with endometriosis were included in the study.
Hale Goksever Celik, Candan Eker, Berivan Guzelbag, Ercan Bastu, Tuba Gunel   +4 more
wiley   +1 more source

The correlation between cell-free DNA and tumour burden was estimated by PET/CT in patients with advanced NSCLC [PDF]

, 2013
BACKGROUND: Cell-free DNA (cfDNA) circulating in the blood holds a possible prognostic value in malignant diseases. Under malignant conditions, the level of cfDNA increases but the biological mechanism remains to be fully understood.
Holdgaard, Paw, Jakobsen, A, Nygaard, A D, Pallisgaard, N, Spindler, K-L G   +4 more
core   +2 more sources

Beyond Traditional Screening: The Future of Heart Failure Detection With Biomarkers and AI

iNew Medicine, EarlyView.
Advancing HF Screening: Integrating Technology and Risk Factors Across Eras. This diagram provides a comprehensive review of the historical developments and projected trends of heart failure (HF) screening methodologies, with the prevalent risk factors for HF depicted at the base.
Xiaofeng Fang, Yinbo Xu, Yiting Zhao, Liuyi Li, Zhengyi Cheng, Zhongqi Zhang, Yuhang Luo, Qiaoling Liu, Chen Gong, Shichun Shen   +9 more
wiley   +1 more source

Enhanced detection of cell-free DNA (cfDNA) enables its use as a reliable biomarker for diagnosis and prognosis of gastric cancer.

PLoS ONE, 2020
Although circulating cell-free DNA (cfDNA) is a promising biomarker for the diagnosis and prognosis of various tumors, clinical correlation of cfDNA with gastric cancer has not been fully understood. To address this, we developed a highly sensitive cfDNA
Jiyoon Bu, Tae Hee Lee, Woo-Jin Jeong, Michael J Poellmann, Kara Mudd, Hyuk Soo Eun, Elizabeth W Liu, Seungpyo Hong, Sung Hee Hyun   +8 more
doaj   +1 more source

The potential for liquid biopsies in the precision medical treatment of breast cancer. [PDF]

, 2016
Currently the clinical management of breast cancer relies on relatively few prognostic/predictive clinical markers (estrogen receptor, progesterone receptor, HER2), based on primary tumor biology.
Barrak, Dany K, Elhodaky, Mostafa, Forte, Victoria A, Lang, Julie E, Snow, Anson, Tung, Lily   +5 more
core   +1 more source

A novel NGS library preparation method to characterize native termini of fragmented DNA. [PDF]

, 2020
Biological and chemical DNA fragmentation generates DNA molecules with a variety of termini, including blunt ends and single-stranded overhangs. We have developed a Next Generation Sequencing (NGS) assay, XACTLY, to interrogate the termini of fragmented ...
Green, Richard E, Harkins, Kelly M, Kapp, Joshua, Naughton, Colin, Rao, Varsha, Schaefer, Nathan K, Shapiro, Beth, Troll, Christopher J   +7 more
core   +1 more source