Results 91 to 100 of about 19,806 (216)

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

Tumors and tumor-like lesions of the gall bladder—A review

Indian Journal of Pathology and Microbiology
Gall bladder carcinoma (GBC) remains a formidable diagnostic and therapeutic challenge, characterized by its often-incidental discovery and diverse spectrum of lesions, spanning from benign mimickers to malignant neoplasms.
Nuzhat Husain, Saumya Shukla, Pallavi Srivastava   +2 more
doaj   +1 more source

Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi, Aaron Zander, Bradley Chan, Leila Syedmoradi, Dev Trivedi, Karolina Elżbieta Kaczor‐Urbanowicz, Fang Wei, Neeti Swarup, Trinity Chan, Mario Romandini, David T. W. Wong   +10 more
wiley   +1 more source

Big Data in Cancer Genomics: Computational Foundations and Emerging Pathways for Precision Oncology

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT This review aims to explore the computational foundations of big data in cancer genomics and examine emerging pathways that support precision oncology and personalized cancer care. A narrative review approach was adopted to synthesize evidence from PubMed, Scopus, Web of Science, and IEEE Xplore.
Nur Vanu, Nur Mohammad, Fahad Ahmed, Towsif Alam, Koushik Saha, Durga Shahi, Adib Hossain, Mia Md. Tofayel Gonee Manik, Mst. Rina Parvin   +8 more
wiley   +1 more source

AGE-ASSOCIATED VARIABILITY OF CIRCULATING FREE DNA CHARACTERISTICS: GENOME-WIDE ANALYSIS

Journal of Bioinformatics and Genomics
The fragments of circulating free DNA (cfDNA) found in plasma are formed due to the genomic DNA degradation during cellular death. The present study is the first research of age-associated variability of cfDNA characteristics performed on the group of ...
Meshkov I.O., Remizova J.A., Makarova A.S., Primova A.A., Petrova V.A., Bukhanova A.A., Kumar N.A., Ivashechkin A.A., Makhotenko A.V., Snigir E.A., Makarov V.V., Yudin V.S., Keskinov A.A., Yudin S.M.   +13 more
doaj   +1 more source

De‐Escalation of Neoadjuvant Treatment for HER2‐Positive Breast Cancer

International Journal of Cancer, Volume 159, Issue 10, Page 2393-2402, 15 November 2026.
ABSTRACT With improved prognosis in early HER2‐positive breast cancer, safely de‐escalating treatment is increasingly investigated to minimize overtreatment. This article focuses on neoadjuvant de‐escalation strategies for HER2‐positive breast cancer.
Yiyin Ma, Dedian Chen, Sheng Huang
wiley   +1 more source

Genome‐wide cfDNA testing of maternal blood [PDF]

Ultrasound in Obstetrics & Gynecology, 2020
Jani J. C., Gil M. M., Benachi A., Prefumo F., Kagan K. O., Tabor A., Bilardo C. M., Di Renzo G. C., Nicolaides K. H.   +8 more
openaire   +5 more sources

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Clinical Impact of CTLA4 and LAG3 Single‐Nucleotide Polymorphisms in Multiple Myeloma Patients Treated With BCMA CAR T‐Cell Therapy

Hematological Oncology, Volume 44, Issue 6, November 2026.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy targeting B‐cell maturation antigen (BCMA) is a highly effective treatment option for patients with relapsed refractory multiple myeloma (RRMM). However, reliable biomarkers predicting long‐term treatment response remain elusive. Germline single‐nucleotide polymorphisms (SNPs) in immune checkpoint
Elisa Suter, Martina Bertschinger, Inna Shaforostova, Marie‐Noelle Kronig, Henning Nilius, Ulrike Bacher, Katja Seipel, Thomas Pabst   +7 more
wiley   +1 more source

Predictive Biomarkers in Metastatic Colorectal Cancer Patients Treated With Bevacizumab: A Turkish Oncology Group (TOG) Study

International Journal of Cancer, Volume 159, Issue 8, Page 2075-2083, 15 October 2026.
Bevacizumab added to systemic chemotherapy remains a cornerstone of metastatic colorectal cancer treatment, but its effectiveness is variable. Tumors can bypass the VEGF blockade by activating other pro‐angiogenic pathways, hampering the identification of predictive biomarkers.
Büsra Akay Hacan, Fatma Gizem Sonugür, Müge Öçal, Cansu Babahan, Samira Abgarmi, Ülkü Yalçıntaş Arslan, Mehmet Ali Şendur, Ahmet Demirkazık, Güngör Utkan, Hakan Akbulut   +9 more
wiley   +1 more source