Results 101 to 110 of about 23,420 (253)

Holistic determination of ends of cfDNA molecules

Cell Genomics
Cell-free DNA (cfDNA) end motifs serve as fragmentomics biomarkers for cancer. Prior studies primarily focused on 5' ends, whereas 3' ends were overlooked due to artifactual modification in existing sequencing protocols. We utilized single-stranded library preparation ("2-end sequencing") to assess the native 5' and 3' end motifs (EM5 and EM3 ...
Jiang, Peiyong, Ma, Mary-Jane L., Qiao, Rong, Shi, Yuwei, Liu, Jing, Zhou, Qing, Peng, Wenlei, Lam, W.K. Jacky, Bai, Jinyue, Choy, L.Y. Lois, Tsui, W.H. Adrian, Malki, Yasine, Kang, Guannan, Yu, Stephanie C.Y., Xiong, Dongyan, Wong, Grace L.H., Chan, Landon L., Wong, John, Chan, Stephen L., Wong, Vincent W.S., Chan, K.C. Allen, Lo, Y.M. Dennis   +21 more
openaire   +2 more sources

Histiocytosis development and clinical variation through the lens of genomics

The Journal of Pathology, EarlyView.
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps, Astrid GS van Halteren, Tom van Wezel, Pancras CW Hogendoorn   +3 more
wiley   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Enhanced detection of cell-free DNA (cfDNA) enables its use as a reliable biomarker for diagnosis and prognosis of gastric cancer.

PLoS ONE, 2020
Although circulating cell-free DNA (cfDNA) is a promising biomarker for the diagnosis and prognosis of various tumors, clinical correlation of cfDNA with gastric cancer has not been fully understood. To address this, we developed a highly sensitive cfDNA
Jiyoon Bu, Tae Hee Lee, Woo-Jin Jeong, Michael J Poellmann, Kara Mudd, Hyuk Soo Eun, Elizabeth W Liu, Seungpyo Hong, Sung Hee Hyun   +8 more
doaj   +1 more source

Cross Sectional Study of Prenatal Diagnosis Uptake Among Individuals With Genetic Conditions

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Prenatal diagnostic genetic testing allows for early identification of significant fetal conditions and enables informed decision‐making regarding management options. The aim of this study was to assess prenatal testing practice among individuals with genetic conditions.
Ebunoluwa Ojo, Roni Zemet, Allyson Nevins, Katherine Abraham, April D. Adams   +4 more
wiley   +1 more source

Mutational concordance between tumor tissue and urine cfDNA.

, 2021
cfDNA, cell-free DNA. (XLSX)
Jeffrey J. Szymanski (11361789), Brian C. Baumann (7431935), Faridi Qaium (11361786), Melissa A. Reimers (11361792), Vivek K. Arora (5702474), Ramandeep K. Babbra (11361765), Wenjia Feng (11361768), Katherine Dienstbach (11361777), Eric H. Kim (4060258), Zachary L. Smith (11361795), Pradeep S. Chauhan (2618257), Kevin Chen (264284), Li Ding (16240), Armaan Nallicheri (11361774), Nadja Pejovic (11361771), Lenon Maguire (11361783), Dengfeng Cao (6382949), Andrew Atkocius (11361780), Aadel A. Chaudhuri (11361798), Peter K. Harris (2312653)   +19 more
core   +1 more source

Extracellular DNA from the blood plasma of patients with schizophrenia stimulates the TLR9-NF-kB signaling pathway in cultured human lymphocytes

Медицинская иммунология
Schizophrenia is a mental illness of complex etiology. Recently, there has been increased interest in the role of the immune system in the pathophysiology of mental disorders.
E. S. Ershova, E. M. Jestkova, E. A. Savinova, S. E. Kostyuk, Т. A. Salimova, N. N. Veiko   +5 more
doaj   +1 more source

The cfDNA in early cancer detection

Basic & Clinical Cancer Research
The Article Abstract is not ...
Hussein Adil Abid, Shukrya Hatem Alwan
openaire   +2 more sources

Prenatal Screening Via cfDNA – Paired‐End Sequencing Utilizing Fragment Size Information Reduces the Screen Positive Rate for X Chromosome Aneuploidies

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Prenatal cfDNA screening has transformed care, yet it remains difficult to determine whether X aneuploidy signals originate from the patient or fetus, inflating screen positive and false positive rates. One potential solution is to incorporate fragment size data from paired‐end sequencing (PES).
Susan Hancock, Franchesca Liao, Theresa Boomer, Sung Kim, Eileen de Feo   +4 more
wiley   +1 more source

What fraction of cellular DNA turnover becomes cfDNA?

Cell-free DNA (cfDNA) tests use small amounts of DNA in the bloodstream as biomarkers. While it is thought that cfDNA is largely released by dying cells, the proportion of dying cells' DNA that reaches the bloodstream is unknown.
Elad Noor, Ron Sender, Yuval Dor, Ron Milo   +3 more
core   +1 more source