Results 101 to 110 of about 29,683 (253)

From DNA Methylation Microarray to Digital PCR: A Stepwise Strategy for Tissue Specific cfDNA Biomarker Development

Journal of Clinical Laboratory Analysis, EarlyView.
Overview of a DNA methylation biomarker development pipeline, from discovery and assay design to screening, performance evaluation, and specificity testing in clinical sample matrices. ABSTRACT Background Tissue‐specific cell‐free DNA (cfDNA) offers promise as a minimally invasive biomarker of organ injury.
David H. Murray, Nicky Boulter, Shanon Ranjit, Natasha M. Rogers, Sarah Kummerfeld, Jason P. Ross, Rodney J. Scott   +6 more
wiley   +1 more source

Tumors and tumor-like lesions of the gall bladder—A review

Indian Journal of Pathology and Microbiology
Gall bladder carcinoma (GBC) remains a formidable diagnostic and therapeutic challenge, characterized by its often-incidental discovery and diverse spectrum of lesions, spanning from benign mimickers to malignant neoplasms.
Nuzhat Husain, Saumya Shukla, Pallavi Srivastava   +2 more
doaj   +1 more source

Recent Advances in Thalassemia Research: A Comprehensive Assessment From Diagnostic Technologies to Clinical Treatment

Journal of Clinical Laboratory Analysis, EarlyView.
Thalassemia, a common hereditary blood disorder causing impaired globin synthesis and related complications, has seen remarkable progress in recent years due to advancements in genomics and molecular biology. Researchers have identified various gene variants related to thalassemia and improved clinical diagnostic methods, including new genetic testing ...
Chaoqiong Zhou, Ting Chen, Ying Huang, Huali Wang, Dahai He, Feng Wu, Yan Zhang, Lirui Kong   +7 more
wiley   +1 more source

Effect of blood pressure and glycemic control on the plasma cell-free DNA in hemodialysis patients

Kidney Research and Clinical Practice, 2015
Background: The plasma levels of cell-free DNA (cfDNA) are known to be elevated under inflammatory or apoptotic conditions. Increased cfDNA levels have been reported in hemodialysis (HD) patients.
Da Wun Jeong, Ju-Young Moon, Young-Wook Choi, Haena Moon, Kipyo Kim, Yu-Ho Lee, Se-Yeun Kim, Yang-Gyun Kim, Kyung-Hwan Jeong, Sang-Ho Lee   +9 more
doaj   +1 more source

Assessment of Potential Sources of Variability on the Analytical Performance of a Circulating Tumor DNA Minimal Residual Disease Test for B‐Cell Lymphomas

Journal of Clinical Laboratory Analysis, EarlyView.
Laboratory tests must exhibit robustness to common sources of test variability, particularly for tests with the potential to inform treatment decisions. This study presents data that shows that a phased variant enrichment and detection sequencing (PhasED‐Seq)‐based circulating tumor DNA minimal residual disease (ctDNA‐MRD) test is robust, with results ...
Nina Klimova, Alanna Roff, Justine McCutcheon, Alex Aheimer, Sandra L. Close, Richard D. Hockett, Stephanie Meek, Laura Hyland   +7 more
wiley   +1 more source

Revisiting Epidermal Growth Factor Receptor (EGFR) Amplification as a Target for Anti-EGFR Therapy: Analysis of Cell-Free Circulating Tumor DNA in Patients With Advanced Malignancies. [PDF]

, 2019
PurposeTo date, evidence for tissue epidermal growth factor receptor (EGFR) overexpression as a biomarker for anti-EGFR therapies has been weak. We investigated the genomic landscape of EGFR amplification in blood-derived cell-free tumor DNA (cfDNA ...
Fanta, Paul T, Goodman, Aaron, Kato, Shumei, Kurzrock, Razelle, Lanman, Richard B, Lee, Suzanna, Lippman, Scott M, Mareboina, Manvita, Okamura, Ryosuke, Patel, Sandip P, Raymond, Victoria M, Schwab, Richard B, Sicklick, Jason K, Vu, Peter   +13 more
core   +1 more source

Estrogen receptor mutations and splice variants determined in liquid biopsies from metastatic breast cancer patients [PDF]

, 2017
Mutations and splice variants in the estrogen receptor (ER) gene, ESR1, may yield endocrine resistance in metastatic breast cancer (MBC) patients. These putative endocrine resistance markers are likely to emerge during treatment, and therefore, its ...
Beije, N. (Nick), Brouwer, A. (Anja), Dirix, L.Y. (Luc), Foekens, J.A. (John), Hamberg, A.P. (Paul), Jager, A. (Agnes), Jansen, M.P.H.M. (Maurice), Jongh, F.E. (Felix) de, Kraan, J. (Jaco), Martens, J.W.M. (John), Onstenk, W. (Wendy), Seynaeve, C.M. (Caroline), Sieuwerts, A.M. (Anieta), Sleijfer, S. (Stefan), van der Vlugt-Daane, M. (Michelle), Van, N.M. (Ngoc M.), Vitale, S.R. (Silvia R.)   +16 more
core   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Plasma cfDNA as a Potential Biomarker to Evaluate the Efficacy of Chemotherapy in Gastric Cancer

Cancer Management and Research, 2020
Yuejiao Zhong,1,* Qingyu Fan,2,* Zhaofei Zhou,1 Yajing Wang,1 Kang He,1 Jianwei Lu1 1Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, People’s Republic of ...
Zhong Y, Fan Q, Zhou Z, Wang Y, He K, Lu J   +5 more
doaj  

Comparison of two high-throughput semiconductor chip sequencing platforms in noninvasive prenatal testing for Down syndrome in early pregnancy [PDF]

, 2016
Background: Noninvasive prenatal testing (NIPT) to detect fetal aneuploidy using next-generation sequencing on ion semiconductor platforms has become common. There are several sequencers that can generate sufficient DNA reads for NIPT.
A Fortuny, A Tabor, AB Sparks, B Langmead, BF Crandall, Byung Chul Kim, C Liao, CJ McNamara, DW Bianchi, E Wang, FR Grati, G Ashoor, GE Palomaki, GP Henry, H Li, Hee Jae Joo, HeeJung Jung, Hongliang Chen, Hwanjong Kwak, Hyungsik Chu, JeongSub Kwon, JF Boland, Jong Bhak, K Song, KC Chan, KH Nicolaides, Kyudong Han, M Ehrich, M Smid, MA Quail, ME Norton, Min Gyun Kim, MJKT Barch, N Vrachnis, P Benn, R Li, S Chen, S Morgan, SeungJae Lee, Sung Hee Han, Sunghoon Park, Sunshin Kim, TK Lau, Y Wang, Y Wang, Y Yuan, YJ Jeon, YM Lo, YM Lo   +48 more
core   +1 more source