STADE-HF (sST2 As a help for management of HF): a pilot study [PDF]
ESC Heart Failure, 2020 Aims Biomarkers are not recommended until now to guide the management of patients with heart failure (HF). Soluble suppression of tumorigenicity 2 (sST2) appears as a promising biomarker. The current study considered pre‐discharged sST2 values as a guide
Fabien Huet +2 more
exaly +4 more sources
Association of sST2 with liver function in patients with acute heart failure related hospitalization [PDF]
Frontiers in Cardiovascular MedicineObjectiveThis study aimed to investigate the association between serum soluble ST2 (sST2) and liver injury biomarkers in patients with acute heart failure (AHF), and to evaluate the potential value of sST2 in identifying liver injury in AHF.MethodsA ...
Zhenyi Liu +4 more
doaj +2 more sources
Targeting ANGPTL3 and IL-33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis. [PDF]
Adv Sci (Weinh)Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Li Z +8 more
europepmc +2 more sources
Exploring serum sST2 and miR-223 as potential biomarkers of disease activity and clinical response to SLIT in HDM-induced allergic rhinitis [PDF]
Scientific ReportsSoluble suppression of tumorigenicity 2 (sST2), a decoy receptor of interleukin-33 (IL-33), is involved in allergic inflammation and may serve as a biomarker in allergic rhinitis (AR).
Ghada A. Mokhtar +11 more
doaj +2 more sources
WAT-to-BAT communication facilitates the sustained activation of BAT thermogenesis during cold exposure [PDF]
Cell DiscoveryThe activation of brown adipose tissue (BAT) for thermogenesis represents a crucial physiological mechanism that helps maintain body temperature during cold exposure.
Jieyuan Xue +11 more
doaj +2 more sources
Elevated sST2 associates with cardiac involvement and declines after treatment in newly diagnosed patients with idiopathic inflammatory myopathies [PDF]
Arthritis Research & TherapyObjective Cardiac involvement (CI) is a major determinant of poor prognosis in idiopathic inflammatory myopathies (IIM). Soluble suppression of tumorigenicity 2 (sST2) is a biomarker linked to cardiac inflammation and remodelling, but its role has ...
Balsam Hanna +7 more
doaj +2 more sources
Epigenetic regulation of SST2 expression in small intestinal neuroendocrine tumors
Frontiers in Endocrinology, 2023 BackgroundSomatostatin receptor type 2 (SST2) expression is critical for the diagnosis and treatment of neuroendocrine tumors and is associated with improved patient survival.
Maria J. Klomp +13 more
doaj +1 more source
Soluble ST2 levels for predicting the presence and severity of metabolic syndrome
Endocrine Connections, 2021 To explore the relationship between soluble ST2 (sST2) and metabolic syndrome (MetS) and determine whether sST2 levels can predict the presence and severity of MetS.
Xiao Zong +7 more
doaj +1 more source
Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes? [PDF]
PLoS ONE, 2012 Preliminary data mostly from animal models suggest the sST2/IL-33 pathway may have causal relevance for vascular disease and diabetes and thus point to a potential novel inflammatory link to cardiometabolic disease.
Ashley M Miller +16 more
doaj +1 more source
Soluble ST2 as a Useful Biomarker for Predicting Clinical Outcomes in Hospitalized COVID-19 Patients
Diagnostics, 2023 Soluble suppression of tumorigenesis-2 (sST2) is an emerging biomarker for sepsis as well as for heart failure. We investigated the prognostic utility of sST2 for predicting clinical outcomes in hospitalized coronavirus disease 2019 (COVID-19) patients ...
Mikyoung Park +7 more
doaj +1 more source