Results 1 to 10 of about 29,923 (224)

Functional profiling of somatostatin receptors identifies somatostatin receptor subtype 2 as a vulnerability in Succinate Dehydrogenase SDHB-deficient pheochromocytomas and paragangliomas [PDF]

Molecular Biomedicine
Pheochromocytomas and Paragangliomas (PPGL) are rare neuroendocrine tumors with favorable prognosis, although a significant subset (20–25%) progress to metastasis, worsening patient prognosis.
Víctor García-Vioque, Sergio Pedraza-Arevalo, María Trinidad Moreno-Montilla, Esther Rivero-Cortés, Ricardo Blázquez-Encinas, Federica Mangili, Ester Arroba, Aura D. Herrera-Martínez, Michael D. Culler, María Ángeles Gálvez-Moreno, Anne Barlier, Luisa María Botella, Mercedes Robledo, Justo P. Castaño, Alejandro Ibáñez-Costa   +14 more
doaj   +2 more sources

Versatile Functions of Somatostatin and Somatostatin Receptors in the Gastrointestinal System

Frontiers in Endocrinology, 2021
Somatostatin (SST) and somatostatin receptors (SSTRs) play an important role in the brain and gastrointestinal (GI) system. SST is produced in various organs and cells, and the inhibitory function of somatostatin-containing cells is involved in a range ...
Xun Xu
exaly   +3 more sources

Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity

eLife, 2022
Somatostatin is a peptide hormone that regulates endocrine systems by binding to G-protein-coupled somatostatin receptors. Somatostatin receptor 2 (SSTR2) is a human somatostatin receptor and is highly implicated in hormone disorders, cancers, and ...
Yunseok Heo, Eojin Yoon, Ye-Eun Jeon, Ji-Hye Yun, Naito Ishimoto, Hyeonuk Woo, Sam-Yong Park, Ji-Joon Song, Weontae Lee   +8 more
doaj   +1 more source

Somatostatin Receptors and Analogs in Pheochromocytoma and Paraganglioma: Old Players in a New Precision Medicine World

Frontiers in Endocrinology, 2021
Neuroendocrine tumors overexpress somatostatin receptors, which serve as important and unique therapeutic targets for well-differentiated advanced disease.
Mayank Patel, Isabel Tena, Isabel Tena, Abhishek Jha, David Taieb, Karel Pacak   +5 more
doaj   +1 more source

Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms

Biomedicines, 2021
Neuroendocrine neoplasms (NENs) are heterogeneous neoplasms which arise from neuroendocrine cells that are distributed widely throughout the body. Although heterogenous, many of them share their ability to overexpress somatostatin receptors (SSTR) on ...
Maria Isabel del Olmo-Garcia, Stefan Prado-Wohlwend, Alexia Andres, Jose M. Soriano, Pilar Bello, Juan Francisco Merino-Torres   +5 more
doaj   +1 more source

Molecular targets in acromegaly

Frontiers in Endocrinology, 2022
Molecular therapeutic targets in growth hormone (GH)-secreting adenomas range from well-characterized surface receptors that recognize approved drugs, to surface and intracellular markers that are potential candidates for new drug development.
Artak Labadzhyan, Shlomo Melmed
doaj   +1 more source

Detection of somatostatin receptors in human osteosarcoma

World Journal of Surgical Oncology, 2008
Background The location of osteosarcoma in the metaphysis as well as the age of the patients during the most rapid tumour growth suggest that factors related to skeletal growth are involved in the pathogenesis of this tumour.
Iakovidou Ioanna, Papanastassiou Ioannis, Papagelopoulos Panayiotis J, Ioannou Markos, Kottakis Stamatios, Demertzis Nikolaos   +5 more
doaj   +1 more source

Evaluation of the expression of somatostatin receptors by immunohistochemistry in neuroendocrine tumors of the small intestine

Polish Journal of Pathology, 2020
Most neuroendocrine neoplasms (NEN) are characterized by the presence of somatostatin receptors (SSTR) which we use in location diagnostics and treatment.
Paweł Gut, Agata Czarnywojtek, Nadia Sawicka-Gutaj, Kosma Woliński, Małgorzata Janicka-Jedyńska, Katarzyna Bednarek-Rajewska, Katarzyna Furman, Marta Fichna, Marek Ruchała   +8 more
doaj   +1 more source

False-positive 111 In-pentetreotide Uptake in Gastritis

World Journal of Nuclear Medicine, 2013
111 In-pentetreotide [ 111 In-octreoscan] is the most widely used radiolabeled somatostatin analog for evaluating neuroendocrine tumor overexpression of somatostatin receptors.
Sharjeel Usmani, Alshaima Alshammari
doaj   +1 more source

Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach

Scientific Reports, 2023
Somatostatin receptors are clinically validated GPCR biomarkers for diagnosis and treatment of various neuroendocrine tumors (NET). Among the five somatostatin receptors, SST2 and SST3 are associated with apoptosis and cell cycle arrest, making these ...
Mor Oron-Herman, David Kirmayer, Amelie Lupp, Stefan Schulz, Genady Kostenich, Michel Afargan   +5 more
doaj   +1 more source