Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms [PDF]
Biomedicines, 2021 Neuroendocrine neoplasms (NENs) are heterogeneous neoplasms which arise from neuroendocrine cells that are distributed widely throughout the body. Although heterogenous, many of them share their ability to overexpress somatostatin receptors (SSTR) on ...
Maria Isabel del Olmo-Garcia +5 more
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Somatostatin Receptors and Analogs in Pheochromocytoma and Paraganglioma: Old Players in a New Precision Medicine World [PDF]
Frontiers in Endocrinology, 2021 Neuroendocrine tumors overexpress somatostatin receptors, which serve as important and unique therapeutic targets for well-differentiated advanced disease.
Mayank Patel +5 more
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Somatostatin and Somatostatin Receptors in Tumour Biology. [PDF]
Int J Mol Sci, 2023 Somatostatin (SST), a growth hormone inhibitory peptide, is expressed in endocrine and non-endocrine tissues, immune cells and the central nervous system (CNS). Post-release from secretory or immune cells, the first most appreciated role that SST exhibits is the antiproliferative effect in target tissue that served as a potential therapeutic ...
Kumar U.
europepmc +3 more sources
Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach [PDF]
Scientific Reports, 2023 Somatostatin receptors are clinically validated GPCR biomarkers for diagnosis and treatment of various neuroendocrine tumors (NET). Among the five somatostatin receptors, SST2 and SST3 are associated with apoptosis and cell cycle arrest, making these ...
Mor Oron-Herman +5 more
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Functional profiling of somatostatin receptors identifies somatostatin receptor subtype 2 as a vulnerability in Succinate Dehydrogenase SDHB-deficient pheochromocytomas and paragangliomas [PDF]
Molecular BiomedicinePheochromocytomas and Paragangliomas (PPGL) are rare neuroendocrine tumors with favorable prognosis, although a significant subset (20–25%) progress to metastasis, worsening patient prognosis.
Víctor García-Vioque +14 more
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Expression of somatostatin receptors in hemangioblastomas associated with von Hippel-Lindau disease as a novel diagnostic, therapeutic, and follow-up opportunity: A case report and literature review [PDF]
Archives of Endocrinology and MetabolismSUMMARY Hemangioblastomas associated with von Hippel-Lindau (VHL) disease are frequently multiple and recur during prolonged follow-up. Currently, no systemic treatment is available for these tumors.
Eloá Pereira Brabo +4 more
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Versatile Functions of Somatostatin and Somatostatin Receptors in the Gastrointestinal System [PDF]
Frontiers in Endocrinology, 2021 Somatostatin (SST) and somatostatin receptors (SSTRs) play an important role in the brain and gastrointestinal (GI) system. SST is produced in various organs and cells, and the inhibitory function of somatostatin-containing cells is involved in a range ...
Bilal Haider Shamsi +5 more
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Somatostatin receptors in fibrotic myocardium. [PDF]
PLoS ONEA patient with a neuroendocrine tumor and history of coronary artery disease underwent PET with 68Ga-DOTATATE PET tracer for tumor visualization.
Estibaliz Castillero +9 more
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Exploring key features of selectivity in somatostatin receptors through molecular dynamics simulations [PDF]
Computational and Structural Biotechnology JournalSomatostatin receptors (SSTRs) are widely distributed throughout the human body and play crucial roles in various physiological processes. They are recognized as key targets for both radiotherapy and radiodiagnosis due to their overexpression in several ...
C. Guccione +5 more
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Somatostatin receptors as a new active targeting sites for nanoparticles [PDF]
Saudi Pharmaceutical Journal, 2018 The delivery of nanoparticles through receptor-mediated cell interactions has nowadays a major attention in the area of drug targeting applications. This specific kind of targeting is mediated by localized receptors impeded into the target site with ...
Ahmed A.H. Abdellatif +3 more
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