Results 11 to 20 of about 30,172 (220)

Calcitriol-Mediated Hypercalcemia, Somatostatin Receptors Expression and 25-Hydroxyvitamin D3-1α- Hydroxylase in GIST Tumors [PDF]

Frontiers in Endocrinology, 2022
Hypercalcemia is a common complication in cancer patients Mainly caused by Parathyroid hormone-related protein (PTHrP) secretion and metastasis. Calcitriol secretion is a rare source of hypercalcemia in solid tumors, especially in gastrointestinal ...
Yiraldine Herrera-Martínez, Yiraldine Herrera-Martínez, María José Contreras González, María José Contreras González, Sergio Pedraza-Arévalo, Sergio Pedraza-Arévalo, Maria del Carmen Guerrero Martínez, Maria del Carmen Guerrero Martínez, Ángela Rodrigo Martínez, Ángela Rodrigo Martínez, Alberto González Menchen, Alberto González Menchen, Maria Angeles Blanco Molina, Maria Angeles Blanco Molina, Maria Angeles Gálvez-Moreno, Maria Angeles Gálvez-Moreno, Alberto L. Moreno-Vega, Alberto L. Moreno-Vega, Raúl M. Luque, Raúl M. Luque, Raúl M. Luque, Aura D. Herrera-Martínez, Aura D. Herrera-Martínez   +22 more
doaj   +2 more sources

Agonists, Antagonists and Receptors of Somatostatin: Pathophysiological and Therapeutical Implications in Neoplasias

Current Issues in Molecular Biology
Somatostatin is a peptide that plays a variety of roles such as neurotransmitter and endocrine regulator; its actions as a cell regulator in various tissues of the human body are represented mainly by inhibitory effects, and it shows potent activity ...
Argyrios Periferakis, Georgios Tsigas, Aristodemos-Theodoros Periferakis, Carla Mihaela Tone, Daria Alexandra Hemes, Konstantinos Periferakis, Lamprini Troumpata, Ioana Anca Badarau, Cristian Scheau, Ana Caruntu, Ilinca Savulescu-Fiedler, Constantin Caruntu, Andreea-Elena Scheau   +12 more
doaj   +3 more sources

Somatostatin Receptors in Human Meningiomas—Clinicopathological Aspects [PDF]

Cancers, 2021
Patricia Mjønes, Sverre Helge Torp, Øyvind Salvesen   +2 more
exaly   +2 more sources

Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity

eLife, 2022
Somatostatin is a peptide hormone that regulates endocrine systems by binding to G-protein-coupled somatostatin receptors. Somatostatin receptor 2 (SSTR2) is a human somatostatin receptor and is highly implicated in hormone disorders, cancers, and ...
Yunseok Heo, Eojin Yoon, Ye-Eun Jeon, Ji-Hye Yun, Naito Ishimoto, Hyeonuk Woo, Sam-Yong Park, Ji-Joon Song, Weontae Lee   +8 more
doaj   +1 more source

Molecular targets in acromegaly

Frontiers in Endocrinology, 2022
Molecular therapeutic targets in growth hormone (GH)-secreting adenomas range from well-characterized surface receptors that recognize approved drugs, to surface and intracellular markers that are potential candidates for new drug development.
Artak Labadzhyan, Shlomo Melmed
doaj   +1 more source

Somatostatin and somatostatin receptors in retinal diseases [PDF]

European Journal of Endocrinology, 2000
Somatostatin is a small neuropeptide that is producedin the central nervous system, where it acts as aneurotransmitter. This neuropeptide also has animportant role in the neuroendocrine system as aninhibitor of hormone release, the most strikingexample of which is the inhibition of growth hormonerelease.
van, Hagen PM, Baarsma, GS, Mooy, CM, Ercoskan, EM, ter, Averst E, Hofland, LJ, Lamberts, SW, Kuijpers, RW   +7 more
openaire   +4 more sources

Detection of somatostatin receptors in human osteosarcoma

World Journal of Surgical Oncology, 2008
Background The location of osteosarcoma in the metaphysis as well as the age of the patients during the most rapid tumour growth suggest that factors related to skeletal growth are involved in the pathogenesis of this tumour.
Iakovidou Ioanna, Papanastassiou Ioannis, Papagelopoulos Panayiotis J, Ioannou Markos, Kottakis Stamatios, Demertzis Nikolaos   +5 more
doaj   +1 more source

Evaluation of the expression of somatostatin receptors by immunohistochemistry in neuroendocrine tumors of the small intestine

Polish Journal of Pathology, 2020
Most neuroendocrine neoplasms (NEN) are characterized by the presence of somatostatin receptors (SSTR) which we use in location diagnostics and treatment.
Paweł Gut, Agata Czarnywojtek, Nadia Sawicka-Gutaj, Kosma Woliński, Małgorzata Janicka-Jedyńska, Katarzyna Bednarek-Rajewska, Katarzyna Furman, Marta Fichna, Marek Ruchała   +8 more
doaj   +1 more source

False-positive 111 In-pentetreotide Uptake in Gastritis

World Journal of Nuclear Medicine, 2013
111 In-pentetreotide [ 111 In-octreoscan] is the most widely used radiolabeled somatostatin analog for evaluating neuroendocrine tumor overexpression of somatostatin receptors.
Sharjeel Usmani, Alshaima Alshammari
doaj   +1 more source

Somatostatin receptors

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2003
In 1972, Brazeau et al. isolated somatostatin (somatotropin release-inhibiting factor, SRIF), a cyclic polypeptide with two biologically active isoforms (SRIF-14 and SRIF-28). This event prompted the successful quest for SRIF receptors. Then, nearly a quarter of a century later, it was announced that a neuropeptide, to be named cortistatin (CST), had ...
Møller, Lars Neisig, Stidsen, Carsten Enggaard, Hartmann, Bolette, Holst, Jens Juul   +3 more
openaire   +2 more sources