Results 21 to 30 of about 587,245 (265)

Competitive RT-PCR Strategy for Quantitative Evaluation of the Expression of Tilapia (Oreochromis niloticus) Growth Hormone Receptor Type I

Biological Procedures Online, 2009
Quantization of gene expression requires that an accurate measurement of a specific transcript is made. In this paper, a quantitative reverse transcription-polymerase chain reaction (RT-PCR) by competition for tilapia growth hormone receptor type I is ...
Rodríguez-Mallon Alina, Cárdenas Yamilet, Lugo Juana, Oliva Aymé, Morales Antonio, Estrada Mario   +5 more
doaj   +3 more sources

Comparative study of somatostatin-human serum albumin fusion proteins and natural somatostatin on receptor binding, internalization and activation.

PLoS ONE, 2014
Albumin fusion technology, the combination of small molecular proteins or peptides with human serum albumin (HSA), is an effective method for improving the medicinal values of natural small molecular proteins or peptides.
Ying Peng, Lili Deng, Yuedi Ding, Quancheng Chen, Yu Wu, Meilin Yang, Yaping Wang, Qiang Fu   +7 more
doaj   +1 more source

Lanreotide, a Somatostatin Analogue, in Advanced Merkel Cell Carcinoma: A Prospective Single-Arm Phase II Study. [PDF]

Cancer Med
ABSTRACT Background Merkel Cell Carcinoma (MCC) is a rare, aggressive neuroendocrine and epithelial skin cancer. Somatostatin analogues, such as lanreotide, have shown efficacy in managing other neuroendocrine tumors. Retrospective studies suggest that lanreotide may induce partial response or disease stabilization in patients with advanced MCC.
Charles J, Belbezier A, Mouret S, Dreno B, Dalle S, Lebbe C, Hainaut-Wierzbicka E, Stefan A, de Quatrebarbes J, Dereure O, Zehou O, Mansard S, Dupuy A, Dutriaux C, Grange F, Gaudy-Marqueste C, Montaudié H, Arnault JP, Le Corre Y, Kervarrec T, Quesada JL, Samimi M, Leccia MT, Group of Cutaneous Oncology of the French Society of Dermatology.   +23 more
europepmc   +2 more sources

The somatostatinergic system in the mammalian cochlea

BMC Neuroscience, 2011
Background Little is known about expression and function of the somatostatinergic system in the mammalian cochlea. We have previously shown that somatostatin administration may have a protective effect on gentamicin-induced hair cell loss. In this study,
Kapfhammer Josef P, Brand Yves, Setz Cristian, Hanusek Claudia, Radojevic Vesna, Bodmer Daniel   +5 more
doaj   +1 more source

A transplantable phosphorylation probe for direct assessment of G protein-coupled receptor activation. [PDF]

PLoS ONE, 2012
The newly developed multireceptor somatostatin analogs pasireotide (SOM230), octreotide and somatoprim (DG3173) have primarily been characterized according to their binding profiles.
Andrea Kliewer, Anika Mann, Aline Petrich, Florian Pöll, Stefan Schulz   +4 more
doaj   +1 more source

Role of mTOR system and its relation with somatostatin and dopamine receptors on cell proliferation, hormone secretion and intracellular signalling in hepatocellular and cholangiocellular carcinomas. [PDF]

, 2011
Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are among the most lethal of human malignancies with s a very poor prognosis, with a
Pivonello, Claudia
core   +1 more source

Somatostatin receptor expression in parathyroid neoplasms

Endocrine Connections, 2019
Introduction: Parathyroid carcinoma represents a rare cause of primary hyperparathyroidism. Distinguishing carcinoma from the benign tumors underlying primary hyperparathyroidism remains challenging.
Sara Storvall, Helena Leijon, Eeva Ryhänen, Johanna Louhimo, Caj Haglund, Camilla Schalin-Jäntti, Johanna Arola   +6 more
doaj   +1 more source

(+)-Trans-Cannabidiol Is an Agonist at Human CB₂ Receptors. [PDF]

Pharmacol Res Perspect
ABSTRACT (−)‐trans‐Cannabidiol ((−)‐CBD) is a principal phytocannabinoid from Cannabis sativa. (−)‐CBD has complex pharmacology but is a relatively weak inhibitor of CB1 and CB2 receptor signaling. Cannabidiol has two chiral centres and thus four stereoisomers.
Burtchaell PB, Santiago MJ, Wang C, Hagdoost M, Clay EJM, Mohnot D, Connor M.   +6 more
europepmc   +2 more sources

Somatostatin and Somatostatin Receptors in Tumour Biology

International Journal of Molecular Sciences, 2023
Somatostatin (SST), a growth hormone inhibitory peptide, is expressed in endocrine and non-endocrine tissues, immune cells and the central nervous system (CNS). Post-release from secretory or immune cells, the first most appreciated role that SST exhibits is the antiproliferative effect in target tissue that served as a potential therapeutic ...
openaire   +2 more sources

Somatostatin receptors as a new active targeting sites for nanoparticles

Saudi Pharmaceutical Journal, 2018
The delivery of nanoparticles through receptor-mediated cell interactions has nowadays a major attention in the area of drug targeting applications. This specific kind of targeting is mediated by localized receptors impeded into the target site with ...
Ahmed A.H. Abdellatif, Sa'ed M. Aldalaen, Waleed Faisal, Hesham M. Tawfeek   +3 more
doaj   +1 more source