Results 11 to 20 of about 587,245 (265)

Somatostatin receptors

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1995
Somatostatin induces its biological actions by activating a family of receptor subtypes. The recent cloning of five somatostatin receptor subtypes has led to the development of subtype-selective agonists. These compounds are revealing distinct functions
T. Reisine
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Somatostatin and somatostatin receptors in Cushing's disease [PDF]

Molecular and Cellular Endocrinology, 2008
Cushing's disease is caused by an ACTH secreting pituitary adenoma. Surgery is the treatment of choice and cure rates between 60 and 90% are reported. For patients in which surgery fails, effective medical treatment options are needed.
Hofland, Leo; id_orcid, Hofland, Leo, Hofland, Leo J.   +2 more
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Somatostatin receptors in human adrenal gland tumors--immunohistochemical study. [PDF]

Folia Histochemica et Cytobiologica, 2008
Somatostatin receptors subtypes (SSTR 1-5) were demonstrated in surgically obtained adrenal gland tumors by means of immunohistochemistry (IHC). Results of the present study demonstrate that somatostatin receptors are expressed in adrenal tumors in a ...
Tomasz Stepień, Hanna Pisarek, Robert Kubiak, Marek Pawlikowski   +3 more
doaj   +2 more sources

Somatostatin receptors in GtoPdb v.2023.1 [PDF]

, 2023
Somatostatin (somatotropin release inhibiting factor) is an abundant neuropeptide, which acts on five subtypes of somatostatin receptor (SST1-SST5; nomenclature as agreed by the NC-IUPHAR Subcommittee on Somatostatin Receptors [98]).
Patel, Yogesh C., Jean-Claude Reubi, Pascal Dournaud, Epelbaum, Jacques, Castaño, Justo P., Daniel Hoyer, Hans-Jürgen Kreienkamp, Reubi, Jean-Claude, Zsolt Csaba, Tulipano, Giovanni, Anthony Harmar, Csaba, Zsolt, Melmed, Shlomo, Wolfgang Meyerhof, Patrick P. A. Humphrey, Hofland, Leo, Hills, Rebecca, Wester, Hans-Jürgen, Reisine, Terry, Amelie Lupp, Rebecca Hills, John E. Taylor, Annamaria Vezzani, Meyerhof, Wolfgang, Jacques Epelbaum, Schindler, Marcus, Wasyl Feniuk, Schonbrunn, Agnes, Shlomo Melmed, Herbert Schmid, Bosquet, Corinne, Schulz, Stefan, Micheal Culler, Lupp, Amelie, Stefan Schulz, Leo Hofland, Kreienkamp, Hans-Jürgen, Schmid, Herbert, Corinne Bosquet, Anne-Marie O'Carroll, O\u27Carroll, Anne-Marie, Culler, Micheal, Taylor, John E., Hans-Jürgen Wester, Justo P. Castaño, Terry Reisine, Giovanni Tulipano, Dournaud, Pascal, Hoyer, Daniel, Humphrey, Patrick P. A., Feniuk, Wasyl, Agnes Schonbrunn, Yogesh C. Patel, Marcus Schindler, Vezzani, Annamaria, Harmar, Anthony   +55 more
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Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas. [PDF]

Mol Oncol
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Taqvi A, Huynh TK, Kadam A, Kardan Z, Yan Y, Laham AJ, Loganathan SK.   +6 more
europepmc   +2 more sources

Somatostatin and somatostatin receptors in retinal diseases [PDF]

European Journal of Endocrinology, 2000
Somatostatin is a small neuropeptide that is producedin the central nervous system, where it acts as aneurotransmitter. This neuropeptide also has animportant role in the neuroendocrine system as aninhibitor of hormone release, the most strikingexample of which is the inhibition of growth hormonerelease.
van, Hagen PM, Baarsma, GS, Mooy, CM, Ercoskan, EM, ter, Averst E, Hofland, LJ, Lamberts, SW, Kuijpers, RW   +7 more
openaire   +4 more sources

Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes [PDF]

, 2012
Conjugates of a dicarba analogue of octreotide, a potent somatostatin agonist whose receptors are overexpressed on tumor cells, with [PtCl 2(dap)] (dap = 1-(carboxylic acid)-1,2-diaminoethane) (3), [(η 6-bip)Os(4-CO 2-pico)Cl] (bip = biphenyl, pico ...
González, Carlos A., Moreno Martínez, Virtudes, Carrion-Salip, Dolors, González-Cantó, A., Massaguer, A., Sadler, Peter, Llorens Duran, Rafael de, Massaguer i Vall-llovera, Anna, González Ibañez, Carlos, Massaguer, Anna, de Llorens, Rafael, Carrion-Salip, D, González, Carlos, Gómez-Pinto, Irene, Sadler, P. J., Moreno, Virtudes, Barragán, F., Barragán, Flavia, Sadler, P.J., Llorens, Rafael de, Marchán Sancho, Vicente, Sadler, Peter J., Carrion Salip, Dolors, Marchán, Vicente, González-Cantó, Alejandro   +24 more
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Somatostatin in the rat periventricular nucleus: sex differences and effect of gonadal steroids [PDF]

, 2008
In the rat, the sexual dimorphism in growth hormone release is driven by sex steroids, and is suggested to result mainly from differences in somatostatin (SOM) release patterns from the median eminence.
Van de Heijning, Bert J M, Van Vugt, Harmke H, Harmke H. Van Vugt, Bert J. M. Van de Heijning, van der Beek, E.M., van Vugt, H.H., Vugt, H.H., van, Beek, E.M., van der, Van der Beek, Eline M; id_orcid, Van der Beek, Eline M, van de Heijning, B.J.M., Heijning, B.J.M., van de, Eline M. Van der Beek   +12 more
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Somatostatin receptors

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2003
In 1972, Brazeau et al. isolated somatostatin (somatotropin release-inhibiting factor, SRIF), a cyclic polypeptide with two biologically active isoforms (SRIF-14 and SRIF-28). This event prompted the successful quest for SRIF receptors. Then, nearly a quarter of a century later, it was announced that a neuropeptide, to be named cortistatin (CST), had ...
Møller, Lars Neisig, Stidsen, Carsten Enggaard, Hartmann, Bolette, Holst, Jens Juul   +3 more
openaire   +2 more sources

Activation of Muscarinic Acetylcholine Receptor Subtype 4 is Essential for Cholinergic Stimulation of Gastric Acid Secretion - Relation To D Cell/Somatostatin -

Frontiers in Pharmacology, 2016
Background/Aim: Muscarinic acetylcholine receptors exist in five subtypes (M1~M5), and they are widely expressed in various tissues to mediate diverse autonomic functions, including gastric secretion.
Koji Takeuchi, Koji Takeuchi, Takuya Endoh, Shusaku Hayashi, Takeshi Aihara   +4 more
doaj   +1 more source