Results 41 to 50 of about 587,245 (265)
Diffuse somatostatin-immunoreactive D-cell hyperplasia in the stomach and duodenum [PDF]
, 1986 This paper presents the first case of extensive, diffuse, somatostatin- immunoreactive D-cell hyperplasia in the human stomach and duodenum. It occurred in a 37-yr-old woman, who showed clinical signs of dwarfism, obesity, dryness of the mouth, and ...
Eisenmenger, Wolfgang +4 more
core +1 more source
Somatostatin receptors in GtoPdb v.2025.3 [PDF]
Somatostatin (somatotropin release inhibiting factor) is an abundant neuropeptide, which acts on five subtypes of somatostatin receptor (SST1-SST5; nomenclature as agreed by the NC-IUPHAR Subcommittee on Somatostatin Receptors [101]). Activation of these
Patel, Yogesh C. +27 more
core +1 more source
Charting Endocrine Progenitors Across Species and Organs
Advanced Science, EarlyView.Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing +21 more
wiley +1 more source
Overview of Radiolabeled Somatostatin Analogs for Cancer Imaging and Therapy
Molecules, 2020 Identified in 1973, somatostatin (SST) is a cyclic hormone peptide with a short biological half-life. Somatostatin receptors (SSTRs) are widely expressed in the whole body, with five subtypes described. The interaction between SST and its receptors leads
Romain Eychenne +5 more
doaj +1 more source
Honey Bee Allatostatins Target Galanin/Somatostatin-Like Receptors and Modulate Learning: A Conserved Function? [PDF]
PLoS ONE, 2016 Sequencing of the honeybee genome revealed many neuropeptides and putative neuropeptide receptors, yet functional characterization of these peptidic systems is scarce. In this study, we focus on allatostatins, which were first identified as inhibitors of
Elodie Urlacher +8 more
doaj +1 more source
Preclinical study of a new 177Lu-labeled somatostatin receptor antagonist in HT-29 human colorectal cancer cells [PDF]
Asia Oceania Journal of Nuclear Medicine and Biology, 2020 Objective(s): Somatostatin receptor-positive neuroendocrine tumors have been targeted using various peptide analogs radiolabeled with therapeutic radionuclides for years.
Hossein Behnammanesh +8 more
doaj +1 more source
Utility of Somatostatin Receptors in Gastrointestinal Tract and Pancreas Neuroendocrine Tumors [PDF]
, 2020 Aim: Neuroendocrine tumors (NETs) are heterogenous group of tumors. Most of gastroenteropancreatic NETs (GEPNETs) are welldifferentiated low-grade tumors but a subset of them displays aggressive behavior.
Isa Burak GUNEY +10 more
core +1 more source
Advanced Science, EarlyView.Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi +7 more
wiley +1 more source
SSTR1 and SSTR5 subtypes are the dominant forms of somatostatin receptor in neuroendocrine tumors.
Folia Histochemica et Cytobiologica, 2010 The effectiveness of the long acting somatostatin analogues like octreotide and lanreotide depends on the expression of specific somatostatin receptors on the target cells.
Jolanta Kunert-Radek +4 more
doaj +1 more source
Frontiers in Endocrinology, 2022 Hypercalcemia is a common complication in cancer patients Mainly caused by Parathyroid hormone-related protein (PTHrP) secretion and metastasis. Calcitriol secretion is a rare source of hypercalcemia in solid tumors, especially in gastrointestinal ...
Yiraldine Herrera-Martínez +22 more
doaj +1 more source