Results 51 to 60 of about 587,245 (265)

Predictors of in vitro response to somatostatin and dopamine receptor-targeted treatments are lacking in clinically non-functioning pituitary tumors. [PDF]

J Neuroendocrinol
Abstract Clinically non‐functioning pituitary neuroendocrine tumors (NF‐PitNETs) lack effective medical therapies, and the role of somatostatin receptor ligands (SRLs) and dopamine agonists (DAs) in this setting is controversial. We evaluated the in vitro response of NF‐PitNETs to multiple SRL and/or DA treatments, focusing on the role of receptor ...
Campana C, Amarù J, Rossi DC, Arecco A, Nozza P, Boschetti M, Zona G, Ferone D, Arvigo M, Gatto F.   +9 more
europepmc   +2 more sources

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Evaluation of new diagnostic and treatment strategies in the management of the Zollinger-Ellison syndrome [PDF]

, 2000
Includes bibliography.Despite major advances over the last two decades with the management of patients with Zollinger-Ellison syndrome (ZES), unanswered questions remain concerning the natural history of the disease, the impact of new diagnostics ...
Radebold, Klaus
core   +1 more source

Unresectable Recurrent Multiple Meningioma: A Case Report with Radiological Response to Somatostatin Analogues

Case Reports in Oncology, 2016
Medical treatment of meningiomas is reserved for cases in which surgery and radiotherapy have failed. Given that a high percentage of meningiomas express somatostatin receptors, treatment with somatostatin analogues has been proposed.
Ana Ortolá Buigues, Irene Crespo Hernández, Manuela Jorquera Moya, Jose Ángel Díaz Pérez   +3 more
doaj   +1 more source

A computational study of somatostatin subtype-4 receptor agonist binding

SN Applied Sciences, 2022
The somatostatin subtype-4 receptor (sst4) is highly expressed in neocortical and hippocampal areas, which are affected by amyloid beta accumulation. Sst4 agonists enhance downstream activity of amyloid beta peptide catabolism through neprilysin and may ...
Olivia Slater, Maria Kontoyianni
doaj   +1 more source

Bidirectional plasticity of GABAergic tonic inhibition in hippocampal somatostatin- and parvalbumin-containing interneurons

Frontiers in Cellular Neuroscience, 2023
GABAA receptors present in extrasynaptic areas mediate tonic inhibition in hippocampal neurons regulating the performance of neural networks. In this study, we investigated the effect of NMDA-induced plasticity on tonic inhibition in somatostatin- and ...
Marcin Wyroślak, Grzegorz Dobrzański, Jerzy W. Mozrzymas   +2 more
doaj   +1 more source

Illuminating somatostatin analog action at neuroendocrine tumor receptors

, 2013
Somatostatin analogs for the diagnosis and therapy of neuroendocrine tumors (NETs) have been used in clinical applications for more than two decades.
Reubi, Jean-Claude, Schonbrunn, Agnes
core   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Somatostatin Serves a Modulatory Role in the Mouse Olfactory Bulb: Neuroanatomical and Behavioral Evidence

Frontiers in Behavioral Neuroscience, 2019
Somatostatin (SOM) and somatostatin receptors (SSTR1–4) are present in all olfactory structures, including the olfactory bulb (OB), where SOM modulates physiological gamma rhythms and olfactory discrimination responses.
Sonia Nocera, Sonia Nocera, Axelle Simon, Axelle Simon, Oriane Fiquet, Oriane Fiquet, Ying Chen, Ying Chen, Jean Gascuel, Frédérique Datiche, Nanette Schneider, Jacques Epelbaum, Jacques Epelbaum, Cécile Viollet, Cécile Viollet   +14 more
doaj   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source