Results 51 to 60 of about 57,261 (251)

Overview of Radiolabeled Somatostatin Analogs for Cancer Imaging and Therapy

Molecules, 2020
Identified in 1973, somatostatin (SST) is a cyclic hormone peptide with a short biological half-life. Somatostatin receptors (SSTRs) are widely expressed in the whole body, with five subtypes described. The interaction between SST and its receptors leads
Romain Eychenne, Christelle Bouvry, Mickael Bourgeois, Pascal Loyer, Eric Benoist, Nicolas Lepareur   +5 more
doaj   +1 more source

Calcitriol-Mediated Hypercalcemia, Somatostatin Receptors Expression and 25-Hydroxyvitamin D3-1α- Hydroxylase in GIST Tumors

Frontiers in Endocrinology, 2022
Hypercalcemia is a common complication in cancer patients Mainly caused by Parathyroid hormone-related protein (PTHrP) secretion and metastasis. Calcitriol secretion is a rare source of hypercalcemia in solid tumors, especially in gastrointestinal ...
Yiraldine Herrera-Martínez, Yiraldine Herrera-Martínez, María José Contreras González, María José Contreras González, Sergio Pedraza-Arévalo, Sergio Pedraza-Arévalo, Maria del Carmen Guerrero Martínez, Maria del Carmen Guerrero Martínez, Ángela Rodrigo Martínez, Ángela Rodrigo Martínez, Alberto González Menchen, Alberto González Menchen, Maria Angeles Blanco Molina, Maria Angeles Blanco Molina, Maria Angeles Gálvez-Moreno, Maria Angeles Gálvez-Moreno, Alberto L. Moreno-Vega, Alberto L. Moreno-Vega, Raúl M. Luque, Raúl M. Luque, Raúl M. Luque, Aura D. Herrera-Martínez, Aura D. Herrera-Martínez   +22 more
doaj   +1 more source

Towards a Radio-guided Surgery with $\beta^{-}$ Decays: Uptake of a somatostatin analogue (DOTATOC) in Meningioma and High Grade Glioma

, 2014
A novel radio guided surgery (RGS) technique for cerebral tumors using $\beta^{-}$ radiation is being developed. Checking the availability of a radio-tracer that can deliver a $\beta^{-}$ emitter to the tumor is a fundamental step in the deployment of ...
BELLINI, Fabio, Bocci, Valerio, Chiodi, Giacomo, COLLAMATI, FRANCESCO, Cremonesi, Marta, DE LUCIA, Erika, FACCINI, Riccardo, Ferrari, Mahila E., Frallicciardi, Paola M., Grana, Chiara M., Marafini, Michela, Mattei, Ilaria, Morganti, Silvio, PATERA, Vincenzo, PEPE, ALESSANDRA, PIERSANTI, LUCA, PINCI, davide, Recchia, Luigi, RUSSOMANDO, ANDREA, SARTI, ALESSIO, SCIUBBA, Adalberto, SENZACQUA, MARTINA, SOLFAROLI CAMILLOCCI, ELENA, VOENA, Cecilia   +23 more
core   +1 more source

Pituitary somatostatin receptor signaling [PDF]

Trends in Endocrinology & Metabolism, 2010
Somatotropin-release inhibitory factor (SRIF) is a major regulator of pituitary function, mostly inhibiting hormone secretion and to a lesser extent pituitary cell growth. Five SRIF receptor subtypes (SSTR1-5) are ubiquitously expressed G-protein coupled receptors.
Anat, Ben-Shlomo, Shlomo, Melmed
openaire   +2 more sources

Photocaged Oxytocin and Vasopressin Probes to Decipher Neuropeptide Signalling With High Spatiotemporal Resolution

Angewandte Chemie International Edition, EarlyView.
Novel and biocompatible photoactivatable oxytocin and vasopressin probes, utilising state‐of‐the‐art photocages, remain inactive in the dark. Light exposure facilitates rapid spatiotemporal receptor activation and phospholipase C (PLC)‐mediated downstream signalling. Figure created in https://BioRender.com.
Konstantin Raabe, Predrag Kalaba, Xuan Ling Hilary Yong, Greta Crudeli, Sarah Melzer, Erik Keimpema, Victor Anggono, Markus Muttenthaler   +7 more
wiley   +1 more source

Unresectable Recurrent Multiple Meningioma: A Case Report with Radiological Response to Somatostatin Analogues

Case Reports in Oncology, 2016
Medical treatment of meningiomas is reserved for cases in which surgery and radiotherapy have failed. Given that a high percentage of meningiomas express somatostatin receptors, treatment with somatostatin analogues has been proposed.
Ana Ortolá Buigues, Irene Crespo Hernández, Manuela Jorquera Moya, Jose Ángel Díaz Pérez   +3 more
doaj   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

A computational study of somatostatin subtype-4 receptor agonist binding

SN Applied Sciences, 2022
The somatostatin subtype-4 receptor (sst4) is highly expressed in neocortical and hippocampal areas, which are affected by amyloid beta accumulation. Sst4 agonists enhance downstream activity of amyloid beta peptide catabolism through neprilysin and may ...
Olivia Slater, Maria Kontoyianni
doaj   +1 more source

Bidirectional plasticity of GABAergic tonic inhibition in hippocampal somatostatin- and parvalbumin-containing interneurons

Frontiers in Cellular Neuroscience, 2023
GABAA receptors present in extrasynaptic areas mediate tonic inhibition in hippocampal neurons regulating the performance of neural networks. In this study, we investigated the effect of NMDA-induced plasticity on tonic inhibition in somatostatin- and ...
Marcin Wyroślak, Grzegorz Dobrzański, Jerzy W. Mozrzymas   +2 more
doaj   +1 more source

Acromegaly: pathogenesis & treatment [PDF]

, 2019
Acromegaly is a multi-system disorder whose etiology is most often traced back to a growth hormone-secreting pituitary adenoma (PA). Growth hormone (GH) secretion promotes insulin-like growth factor 1 (IGF-1) release from peripheral tissues, leading to ...
Tilvawala, Megha
core