Results 71 to 80 of about 587,245 (265)

Early Versus Late Recurrence in Olfactory Neuroblastoma: A Multi‐Institutional Analysis of Predictive Risk Factors

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Olfactory neuroblastoma (ONB) exhibits variable recurrence patterns, with significant late recurrences occurring years after treatment. We investigated cutoff periods to define late recurrence and identified predictors that distinguish patients at risk of late recurrence from those considered cured.
Alexandria Harris, Anthony Tang, Nicholas Fung, Joao Paulo Almeida, Pierre‐Olivier Champagne, Juan Fernandez‐Miranda, Paul A. Gardner, Peter Hwang, Aristotelis Kalyvas, Chirag Patel, Zara M. Patel, Maria Peris Celda, Carlos D. Pinheiro‐Neto, Olabisi Sanusi, Carl H. Snyderman, Brian D. Thorp, Jamie J. Van Gompel, Georgios Zenonos, Nathan T. Zwagerman, Diana Bell, Edward C. Kuan, Eric W. Wang, Mathew Geltzeiler, Garret Choby   +23 more
wiley   +1 more source

Pulmonary large cell neuroendocrine carcinoma (LCNEC) with confirmed liver metastases negative on 18F-FDG and 68Ga-DOTATATE PET

Radiology Case Reports, 2020
Lung neuroendocrine neoplasms (NENs) encompass the low-, intermediate-, and high-grade entities. Differentiated NENs overexpress somatostatin receptors, which are targeted by 68Ga-DOTA-conjugated peptides in molecular imaging with positron emission ...
Gaia Ninatti, Heying Duan, MD, Valentina Ferri, MS, Brock A. Martin, MD, Carina Mari Aparici, MD   +4 more
doaj   +1 more source

T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy

Annals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes, Lukas Henning, Karen M. J. van Loo, Rainer Surges, Susanne Schoch, Albert J. Becker, Julika Pitsch   +6 more
wiley   +1 more source

Somatostatin/somatostatin receptor signalling: Phosphotyrosine phosphatases [PDF]

Molecular and Cellular Endocrinology, 2008
Activation of phosphotyrosine phosphatases (PTPs) by somatostatin receptor (SSTR) represents one of the main intracellular mechanisms involved in the antiproliferative effect of somatostatin (SST) and analogues. Since their molecular cloning, the role of PTPs is emerging as a major regulator of different cell functions including cell proliferation ...
openaire   +3 more sources

TARGETING PEPTIDES CONTAINING SUPRAMOLECULAR AGGREGATES TOWARD CANCER CELLS [PDF]

, 2009
Multimodal supramolecular compounds that combine imaging and therapeutic capabilities are the focus of intensive research for applications in the growing field of nanomedicine.
Morisco, Anna
core   +1 more source

Somatostatinergic systems: an update on brain functions in normal and pathological aging

Frontiers in Endocrinology, 2012
Somatostatin is highly expressed in mammalian brain and is involved in many brain functions such as motor activity, sleep, sensory and cognitive processes. Five somatostatin receptors have been described: sst1, sst2 (A and B), sst3 to 5, all belonging to
Guillaume eMartel, Guillaume eMartel, Patrick eDutar, Patrick eDutar, Jacques eEpelbaum, Jacques eEpelbaum, Cécile eViollet, Cécile eViollet   +7 more
doaj   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1-5 and Therapeutic Implications in Neuroendocrine and Non-Neuroendocrine Malignancies. [PDF]

Int J Cancer
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Kumari N, Hoffmann P, Reichl L, Schmutz M, Fischer N, Dang TTV, Ferrazzi F, Johann P, Kuhlen M, Lapa C, Claus R.   +10 more
europepmc   +2 more sources

Pancreatic beta-cell somatostatin receptors

, 1990
The characteristics of somatostatin (SRIF) receptors in rat pancreatic beta-cells were investigated using rat islets and the beta-cell line HIT-T15 (HIT).
K. M. Lounsbury, J. Nelson, M. D. Meglasson, T. Reisine, K. Thermos   +4 more
core   +1 more source

Cholecystokinin and Somatostatin Negatively Affect Growth of the Somatostatin-RIN-14B Cells

International Journal of Endocrinology, 2009
With the exclusive presence of the pancreatic CCK-2 receptors on the pancreatic delta cells of six different species, this study was undertaken to determine the role of cholecystokinin and gastrin on growth of these somatostatin (SS) cells.
Karim El-Kouhen, Jean Morisset
doaj   +1 more source

Somatostatin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. [PDF]

, 2019
Somatostatin (somatotropin release inhibiting factor) is an abundant neuropeptide, which acts on five subtypes of somatostatin receptor (SST1-SST5; nomenclature as agreed by the NC-IUPHAR Subcommittee on Somatostatin Receptors [89]).
Patel, Yogesh C., Bosquet, Corinne, Epelbaum, Jacques, Schulz, Stefan, Humphrey, Patrick, Lupp, Amelie, Taylor, John, Castaño, Justo P., Kreienkamp, Hans-Jürgen, Reubi, Jean-Claude, Schmid, Herbert, Castaño, Justano, Tulipano, Giovanni, Csaba, Zsolt, Melmed, Shlomo, O\u27Carroll, Anne-Marie, Culler, Micheal, Taylor, John E., Hofland, Leo, Hills, Rebecca, Wester, Hans-Jürgen, Reisine, Terry, Patel, Yogesh, Dournaud, Pascal, Meyerhof, Wolfgang, Hoyer, Daniel, Schindler, Marcus, Humphrey, Patrick P. A., Schonbrunn, Agnes, Feniuk, Wasyl, O'Carroll, Anne-Marie, Vezzani, Annamaria, Harmar, Anthony   +32 more
core   +1 more source