Results 11 to 20 of about 8,618 (210)

Prognostic Value of sST2 in Heart Failure

Journal of Clinical Medicine, 2023
In recent years, there has been growing interest in the risk stratification for heart failure, and the use of multiple biomarkers to identify different pathophysiological processes associated with this condition. One such biomarker is soluble suppression of tumorigenicity-2 (sST2), which has shown some potential for integration into clinical practice ...
Sciatti E., Merlo A., Scangiuzzi C., Limonta R., Gori M., D'Elia E., Aimo A., Vergaro G., Emdin M., Senni M.   +9 more
openaire   +4 more sources

Clinical and Prognostic Significance of sST2 in Heart Failure

Journal of the American College of Cardiology, 2019
Soluble suppression of tumorigenesis-2 (sST2) is released in response to vascular congestion and inflammatory and pro-fibrotic stimuli, and is a strong, independent predictor of mortality and heart failure (HF) hospitalization in patients with acute or ...
Alberto Aimo, James L Januzzi, Antoni Bayés-Genís   +2 more
exaly   +3 more sources

Predictive Values of Serum IL-33 and sST2 in Endotypes and Postoperative Recurrence of Chronic Rhinosinusitis with Nasal Polyps

Mediators of Inflammation, 2022
Background. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disease with high heterogeneity and postoperative recidivation. The IL-33/ST2 axis is known to be involved in Th2 immune responses.
Yanni Zhang, Kang Zhu, Jingguo Chen, Cui Xia, Chao Yu, Tianxi Gao, Jing Yan, Bingjie Zhao, Xiaoyong Ren   +8 more
doaj   +2 more sources

Conflicting vascular and metabolic impact of the IL-33/sST2 axis [PDF]

Cardiovascular Research, 2018
Interleukin 33 (IL-33), which is expressed by several immune cell types, endothelial and epithelial cells, and fibroblasts, is a cytokine of the IL-1 family that acts both intra- and extracellularly to either enhance or resolve the inflammatory response. Intracellular IL-33 acts in the nucleus as a regulator of transcription.
Altara, Raffaele, Ghali, Rana, Mallat, Ziad, Cataliotti, Alessandro, Booz, George W, Zouein, Fouad A   +5 more
openaire   +4 more sources

Clinical and prognostic relevance of sST2 in adults with dengue-associated cardiac impairment and severe dengue.

PLoS Neglected Tropical Diseases, 2022
BackgroundDengue can be complicated by severe outcomes including cardiac impairment, and the lack of reliable prognostic biomarkers poses a challenge in managing febrile dengue patients.
Andrew Teo, Po Ying Chia, Gaurav Kumar Ramireddi, Sebastian Kah Ming Khoo, Tsin Wen Yeo   +4 more
doaj   +2 more sources

Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF–nuclear IL-33–GATA3 pathway

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance In the tumor microenvironment of colorectal cancer (CRC), sST2 acts in a tumor-suppressive manner by inhibiting the proinflammatory function of interleukin (IL)-33. This study demonstrates that hypoxia, which is closely associated with tumor
Miho Akimoto, Takao Susa, N. Okudaira, N. Koshikawa, H. Hisaki, Masayoshi Iizuka, H. Okinaga, K. Takenaga, T. Okazaki, M. Tamamori-Adachi   +9 more
semanticscholar   +1 more source

Evaluation of interleukin-33 & sST2 levels in type-2 diabetic mellitus patients with or without metabolic syndrome

The Indian journal of medical research, 2023
Background & objectives: Diabetes mellitus (DM) is characterized by increase in blood glucose levels due to defective insulin secretion or insulin sensitivity. Interleukins (ILs) are known to play an important role in the pathogenesis of DM.
Himadri Singh, S. Khadanga, S. Goel, Syamantak Majumder, Mirza Baig, V. Bhatia, N. Chaudhary, R. Saluja   +7 more
semanticscholar   +1 more source

Soluble ST2 as a Useful Biomarker for Predicting Clinical Outcomes in Hospitalized COVID-19 Patients

Diagnostics, 2023
Soluble suppression of tumorigenesis-2 (sST2) is an emerging biomarker for sepsis as well as for heart failure. We investigated the prognostic utility of sST2 for predicting clinical outcomes in hospitalized coronavirus disease 2019 (COVID-19) patients ...
Mikyoung Park, Mina Hur, Hanah Kim, Chae Hoon Lee, Jong Ho Lee, Hyung Woo Kim, Minjeong Nam, Seungho Lee   +7 more
doaj   +1 more source

Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism

International Journal of Molecular Sciences, 2023
Objective: Pulmonary embolism (PE) is a potentially life-threatening disorder. Beyond its usefulness in the prognostic stratification of heart failure, sST2 can represent a biomarker with high utility in several acute conditions.
L. Petramala, A. Concistré, F. Sarlo, S. Baroni, M. Suppa, A. Servello, F. Circosta, G. Galardo, O. Gandini, Luca Marino, G. Cavallaro, G. Iannucci, C. Letizia   +12 more
semanticscholar   +1 more source

Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes? [PDF]

PLoS ONE, 2012
Preliminary data mostly from animal models suggest the sST2/IL-33 pathway may have causal relevance for vascular disease and diabetes and thus point to a potential novel inflammatory link to cardiometabolic disease.
Ashley M Miller, David Purves, Alex McConnachie, Darren L Asquith, G David Batty, Harry Burns, Jonathan Cavanagh, Ian Ford, Jennifer S McLean, Chris J Packard, Paul G Shiels, Helen Turner, Yoga N Velupillai, Kevin A Deans, Paul Welsh, Iain B McInnes, Naveed Sattar   +16 more
doaj   +1 more source