Results 21 to 30 of about 5,690 (176)

Serum sST2 levels predict severe exacerbation of asthma [PDF]

Respiratory Research, 2018
Neutrophilic inflammation is associated with poorly controlled asthma. Serum levels of sST2, a soluble IL-33 receptor, increase in neutrophilic lung diseases. We hypothesized that high serum sST2 levels in stable asthmatics are a predictor for exacerbation within a short duration.This prospective observational study evaluated the serum sST2 levels of ...
Masato Watanabe, Keitaro Nakamoto, Toshiya Inui, Mitsuru Sada, Kojiro Honda, Masaki Tamura, Yukari Ogawa, Takuma Yokoyama, Takeshi Saraya, Daisuke Kurai, Haruyuki Ishii, Hajime Takizawa   +11 more
openaire   +3 more sources

Increased systemic sST2 in patients with end stage renal disease contributes to milder liver damage during HCV infection

Journal of Infection in Developing Countries, 2020
Introduction: Hepatitis C Virus (HCV) is the leading cause of chronic liver disease and is a serious global health problem. Hepatitis C infection is highly prevalent in patients with end stage renal disease (ESRD), due to frequent exposure to blood and ...
Ruzica Lukic, Maja Cupic, Nevena Gajovic, Milena Jurisevic, Zeljko Mijailovic, Bojana Davidovic, Bojan Kujundzic, Bojan Joksimovic, Nebojsa Arsenijevic, Ivan Jovanovic   +9 more
doaj   +1 more source

Clinical relevance of sST2 in cardiac diseases

Clinical Chemistry and Laboratory Medicine (CCLM), 2016
AbstractST2 has two main isoforms, ST2L and soluble isoform of ST2 (sST2), by alternative splicing. The interaction between interleukin (IL)-33 and the transmembrane isoform ST2L is up-regulated in response to myocardial stress and exerts cardio-protective actions in the myocardium by reducing fibrosis, hypertrophy and enhancing survival.
Pascual Figal, Domingo A., Lax, Antonio, Perez Martinez, Maria T., Asensio Lopez, Maria del Carmen, Sanchez Mas, Jesus, Lax Pérez, Antonio Manuel   +5 more
openaire   +2 more sources

Fates of endocytosed somatostatin sst2 receptors and associated agonists [PDF]

Biochemical Journal, 1998
Somatostatin agonists are rapidly and efficiently internalized with the somatostatin sst2 receptor. The fate of internalized agonists and receptors is of critical importance because the rate of ligand recycling back to the cell surface can limit the amount of radioligand accumulated inside the cells, whereas receptor recycling might be of vital ...
J A, Koenig, R, Kaur, I, Dodgeon, J M, Edwardson, P P, Humphrey   +4 more
openaire   +2 more sources

Soluble ST2 concentrations associate with in-hospital mortality and need for mechanical ventilation in unselected patients with COVID-19

Open Heart, 2021
Objective Soluble ST2 (sST2) reflects inflammation, endothelial dysfunction and myocardial fibrosis, is produced in the lungs and is an established biomarker in heart failure.
Ingebjørg Seljeflot, Torbjørn Omland, Christian Prebensen, Christine Jonassen, My Svensson, Jan Erik Berdal, Peder Langeland Myhre   +6 more
doaj   +1 more source

The Association of Serum IL-33 and sST2 with Breast Cancer [PDF]

Disease Markers, 2015
Breast cancer is one of the most common malignant diseases in women. The main cause of death from breast cancer is its metastases at distant sites in the body. Interleukin-33 (IL-33) is a cytokine of the IL-1 family and found overexpressed in various cancers.
Yang, Zhi-Ping, Ling, Dan-Yan, Xie, Yong-Hong, Wu, Wan-Xin, Li, Jin-Rui, Jiang, Jin, Zheng, Jia-Lian, Fan, Yao-Hua, Zhang, Ye   +8 more
openaire   +2 more sources

Soluble suppression of tumorigenicity 2 (sST2) for predicting disease severity or mortality outcomes in cardiovascular diseases: A systematic review and meta-analysis

International Journal of Cardiology: Heart & Vasculature, 2021
Objectives: Soluble suppression of tumorigenicity 2 (sST2) is a member of the interleukin-1 receptor family. It is raised in various cardiovascular diseases, but its value in predicting disease severity or mortality outcomes has been controversial ...
Christina Ip, King Sum Luk, Vincent Lok Cheung Yuen, Lorraine Chiang, Ching Ki Chan, Kevin Ho, Mengqi Gong, Teddy Tai Loy Lee, Keith Sai Kit Leung, Leonardo Roever, George Bazoukis, Konstantinos Lampropoulos, Ka Hou Christien Li, Gary Tse, Tong Liu   +14 more
doaj   +1 more source

Primary sources and immunological prerequisites for sST2 secretion in humans [PDF]

Cardiovascular Research, 2010
Serum levels of the soluble growth stimulation gene-2 (sST2) are elevated in heart and pulmonary diseases. However, the relationship of the sST2/interleukin (IL)-33 axis and its triggers as well as its organ distribution is still not known. This study was thus designed to investigate the cellular origin and regulation of sST2 and IL-33 in vitro and in ...
Michael, Mildner, Angela, Storka, Michael, Lichtenauer, Veronika, Mlitz, Minoo, Ghannadan, Konrad, Hoetzenecker, Stefanie, Nickl, Balazs, Dome, Erwin, Tschachler, Hendrik Jan, Ankersmit   +9 more
openaire   +2 more sources

Association of IL1R1 Coding Variant With Plasma-Level Soluble ST2 and Risk of Aortic Dissection

Frontiers in Cardiovascular Medicine, 2021
Objective: Aortic dissection (AD) is characterized by an acute onset, rapid progress, and high mortality. Levels of soluble ST2 (sST2) on presentation are elevated in patients with acute AD, which can be used to discriminate AD patients from patients ...
Wenxi Jiang, Wenxi Jiang, Xue Wang, Xue Wang, Pei Gao, Fengjuan Li, Fengjuan Li, Ke Lu, Xin Tan, Xin Tan, Shuai Zheng, Shuai Zheng, Wang Pei, Wang Pei, Meiyu An, Meiyu An, Xi Li, Rong Hu, Yongliang Zhong, Junming Zhu, Jie Du, Jie Du, Yuan Wang, Yuan Wang   +23 more
doaj   +1 more source

sST2: a new kid on the block for patients with ACHD [PDF]

Heart, 2019
Adults with congenital heart disease (ACHD) are an increasing and ageing population.1 Despite all advances in medical and surgical treatment, patients with ACHD are still afflicted by significant morbidity and mortality.2 Timely identification of those patients that are at risk can be difficult.
openaire   +2 more sources