Results 21 to 30 of about 5,477 (176)

The Tyrosine Phosphatase SHP-1 Associates with the sst2 Somatostatin Receptor and Is an Essential Component of sst2-mediated Inhibitory Growth Signaling [PDF]

Journal of Biological Chemistry, 1997
Activation of the somatostatin receptor sst2, a member of the Gi protein-coupled receptor family, results in the stimulation of a protein-tyrosine phosphatase activity involved in the sst2-mediated growth inhibitory signal. Here, we report that SHP-1, a cytoplasmic protein-tyrosine phosphatase containing two Src homology 2 domains constitutively ...
F, Lopez, J P, Estève, L, Buscail, N, Delesque, N, Saint-Laurent, M, Théveniau, C, Nahmias, N, Vaysse, C, Susini   +8 more
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Increased systemic sST2 in patients with end stage renal disease contributes to milder liver damage during HCV infection

Journal of Infection in Developing Countries, 2020
Introduction: Hepatitis C Virus (HCV) is the leading cause of chronic liver disease and is a serious global health problem. Hepatitis C infection is highly prevalent in patients with end stage renal disease (ESRD), due to frequent exposure to blood and ...
Ruzica Lukic, Maja Cupic, Nevena Gajovic, Milena Jurisevic, Zeljko Mijailovic, Bojana Davidovic, Bojan Kujundzic, Bojan Joksimovic, Nebojsa Arsenijevic, Ivan Jovanovic   +9 more
doaj   +1 more source

Fates of endocytosed somatostatin sst2 receptors and associated agonists [PDF]

Biochemical Journal, 1998
Somatostatin agonists are rapidly and efficiently internalized with the somatostatin sst2 receptor. The fate of internalized agonists and receptors is of critical importance because the rate of ligand recycling back to the cell surface can limit the amount of radioligand accumulated inside the cells, whereas receptor recycling might be of vital ...
J A, Koenig, R, Kaur, I, Dodgeon, J M, Edwardson, P P, Humphrey   +4 more
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The IL-33/sST2 Axis in Thromboangiitis Obliterans.

Journal of inflammation research, 2020
Until recently, it remains unknown whether thromboangiitis obliterans (TAO) is a type of systemic vasculitis. A high level of IL-33 and its soluble decoy receptor sST2 in the acute phase of systemic vasculitis has been demonstrated.The serum level of IL-33 and sST2 in 50 TAO patients, 20 age- and smoking habit-matched controls and 19 age-matched non ...
Sharebiani,Hiva, Moharreri,Mehran, Mirhosseini,Ali, Fazeli,Bahare   +3 more
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Soluble ST2 concentrations associate with in-hospital mortality and need for mechanical ventilation in unselected patients with COVID-19

Open Heart, 2021
Objective Soluble ST2 (sST2) reflects inflammation, endothelial dysfunction and myocardial fibrosis, is produced in the lungs and is an established biomarker in heart failure.
Ingebjørg Seljeflot, Torbjørn Omland, Christian Prebensen, Christine Jonassen, My Svensson, Jan Erik Berdal, Peder Langeland Myhre   +6 more
doaj   +1 more source

Clinical relevance of sST2 in cardiac diseases

Clinical Chemistry and Laboratory Medicine (CCLM), 2016
AbstractST2 has two main isoforms, ST2L and soluble isoform of ST2 (sST2), by alternative splicing. The interaction between interleukin (IL)-33 and the transmembrane isoform ST2L is up-regulated in response to myocardial stress and exerts cardio-protective actions in the myocardium by reducing fibrosis, hypertrophy and enhancing survival.
Pascual Figal, Domingo A., Lax, Antonio, Perez Martinez, Maria T., Asensio Lopez, Maria del Carmen, Sanchez Mas, Jesus, Lax Pérez, Antonio Manuel   +5 more
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A pan-cancer analysis of the clinical and genetic portraits of somatostatin receptor expressing tumor as a potential target of peptide receptor imaging and therapy

EJNMMI Research, 2020
Purpose Although somatostatin receptor (SST) is a promising theranostic target and is widely expressed in tumors of various organs, the indication for therapies targeting SST is limited to typical gastroenteropancreatic neuroendocrine tumors (NETs). Thus,
Hyunjong Lee, Minseok Suh, Hongyoon Choi, Seunggyun Ha, Jin Chul Paeng, Gi Jeong Cheon, Keon Wook Kang, Dong Soo Lee   +7 more
doaj   +1 more source

Primary sources and immunological prerequisites for sST2 secretion in humans [PDF]

Cardiovascular Research, 2010
Serum levels of the soluble growth stimulation gene-2 (sST2) are elevated in heart and pulmonary diseases. However, the relationship of the sST2/interleukin (IL)-33 axis and its triggers as well as its organ distribution is still not known. This study was thus designed to investigate the cellular origin and regulation of sST2 and IL-33 in vitro and in ...
Michael, Mildner, Angela, Storka, Michael, Lichtenauer, Veronika, Mlitz, Minoo, Ghannadan, Konrad, Hoetzenecker, Stefanie, Nickl, Balazs, Dome, Erwin, Tschachler, Hendrik Jan, Ankersmit   +9 more
openaire   +2 more sources

Association of IL1R1 Coding Variant With Plasma-Level Soluble ST2 and Risk of Aortic Dissection

Frontiers in Cardiovascular Medicine, 2021
Objective: Aortic dissection (AD) is characterized by an acute onset, rapid progress, and high mortality. Levels of soluble ST2 (sST2) on presentation are elevated in patients with acute AD, which can be used to discriminate AD patients from patients ...
Wenxi Jiang, Wenxi Jiang, Xue Wang, Xue Wang, Pei Gao, Fengjuan Li, Fengjuan Li, Ke Lu, Xin Tan, Xin Tan, Shuai Zheng, Shuai Zheng, Wang Pei, Wang Pei, Meiyu An, Meiyu An, Xi Li, Rong Hu, Yongliang Zhong, Junming Zhu, Jie Du, Jie Du, Yuan Wang, Yuan Wang   +23 more
doaj   +1 more source

sST2: a new kid on the block for patients with ACHD [PDF]

Heart, 2019
Adults with congenital heart disease (ACHD) are an increasing and ageing population.1 Despite all advances in medical and surgical treatment, patients with ACHD are still afflicted by significant morbidity and mortality.2 Timely identification of those patients that are at risk can be difficult.
openaire   +2 more sources