Results 21 to 30 of about 23,420 (253)
Plasma cfDNA in Glioblastoma—Letter [PDF]
Clinical Cancer Research, 2020 We read enthusiastically the recent article by Bagley and colleagues ([1][1]). The authors prospectively investigated plasma cell-free DNA (cfDNA) concentration and mutations in patients with glioblastoma. This is an interesting topic and we commend the authors for their efforts.
Takeshi, Takayasu +2 more
openaire +2 more sources
Immunoaging – the effect of age on serum levels of NET biomarkers in men: a pilot study
International Journal of Occupational Medicine and Environmental Health, 2023 Objectives The study aimed to evaluate the impact of aging on the formation of neutrophil extracellular traps (NETs). The impaired formation of NETs is the cause of an abnormal innate immune response.
Marzena Garley +6 more
doaj +1 more source
Diagnostic Value of cfDNA in Pancreatic Cancer
Zhongliu Fangzhi Yanjiu, 2022 Objective To explore the diagnostic value of cfDNA in pancreatic cancer. Methods A total of 467 patients with pancreatic cancer and 129 healthy controls were enrolled. cfDNA concentration was detected using the QuantiDNA Direct cfDNA Test (DiaCarta) kit.
XU Yijun, ZHU Mingchen
doaj +1 more source
Investigation of Different Library Preparation and Tissue of Origin Deconvolution Methods for Urine and Plasma cfDNA Methylome Analysis. [PDF]
, 2023 Methylation sequencing is a promising approach to infer the tissue of origin of cell-free DNA (cfDNA). In this study, a single- and a double-stranded library preparation approach were evaluated with respect to their technical biases when applied on cfDNA
Banz, Vanessa +11 more
core +1 more source
Adoption of a non-invasive prenatal test (NIPT) in prenatal screening in Moscow: first results
Russian Open Medical Journal, 2021 The objective — To assess the effectiveness of including NIPT in the structure of prenatal diagnostics in Moscow. Material and Methods — Totally 5,181 pregnancies undergoing screening for fetal trisomy using NIPT during the period from 01.04.2020 to 30 ...
Anton S. Olenev +7 more
doaj +1 more source
Acta Medica, 2020 A significant population of ultrashort (50–150n) single-stranded DNA fragments were found in exosome-free blood plasma of retinoblastoma patients (6.84 ng mL−1), but not in plasma of healthy donors.
Kirill V. Ermakov +5 more
doaj +1 more source
Molecular mechanisms of cfDNA effects [PDF]
, 2023 The biological role of free circulating DNA is currently being investigated mainly in terms of the etiology of autoimmune conditions and cancer. It appears that the role of cfDNA of nuclear or mitochondrial origin in interacting with receptors of the ...
Hříbková, Natálie
core +1 more source
Cell-free DNA methylome profiling by MBD-seq with ultra-low input
Epigenetics, 2022 Methylation signatures in cell-free DNA (cfDNA) have shown great sensitivity and specificity in the characterization of tumour status and classification of tumour types, as well as the response to therapy and recurrence. Currently, most cfDNA methylation
Jinyong Huang +2 more
doaj +1 more source
Dynamics of methylated cell-free DNA in the urine of non-small cell lung cancer patients
Epigenetics, 2022 High levels of methylated DNA in urine represent an emerging biomarker for non-small cell lung cancer (NSCLC) detection and are the subject of ongoing research.
Sander Bach +7 more
doaj +1 more source
eLife, 2021 We developed genetic-epigenetic tissue mapping (GETMap) to determine the tissue composition of plasma DNA carrying genetic variants not present in the constitutional genome through comparing their methylation profiles with relevant tissues.
Wanxia Gai +18 more
doaj +1 more source