Results 1 to 10 of about 154 (61)

Cell-free DNA methylome and fragmentome analysis for relapse monitoring of Ewing sarcoma [PDF]

EMBO Molecular Medicine
Liquid biopsies and cell-free DNA (cfDNA) offer minimally invasive methods for the diagnosis and monitoring of Ewing Sarcoma (EwS). EwS have a low tumour mutational burden and their detection with plasma cfDNA is challenging.
Sophie A Richardson, Aram Safrastyan, Mina Karimpour, Gayatri Gulati, Patrick J B Harker, Alan Redfern, Simon P Pearce, Vsevolod J Makeev, Bernadette Brennan, Alexander T J Lee, Alexandra Clipson, Steven M Hill, Caroline Dive, Dominic G Rothwell, Martin G McCabe, Florent Mouliere   +15 more
exaly   +3 more sources

Real‐time analysis of the cancer genome and fragmentome from plasma and urine cell‐free DNA using nanopore sequencing [PDF]

EMBO Molecular Medicine, 2023
Cell‐free DNA (cfDNA) can be isolated and sequenced from blood and/or urine of cancer patients. Conventional short‐read sequencing lacks deployability and speed and can be biased for short cfDNA fragments.
Normastuti Adhini Tantyo, Nils Evander, Birgit M M Wever   +2 more
exaly   +3 more sources

Early detection and subtyping of gastric cancer: A cell-free DNA fragmentome-based liquid biopsy method [PDF]

IScience
Summary: Cell-free DNA (cfDNA) in plasma provides attractive opportunities for early cancer diagnosis. This study aimed to establish gastric cancer (GC) artificial intelligence algorithms (GC-AIAs) based on cfDNA fragmentome for GC’s early detection and ...
Hanqing Zhang
exaly   +4 more sources

Longitudinal cell-free DNA methylome and fragmentome profiles in health uncover signatures of cell type and demographic origin [PDF]

Genome Medicine
Background Cell-free DNA (cfDNA) is a powerful analyte for liquid biopsy applications. However, the composition and fragmentation of cfDNA in health remains incompletely characterized. Understanding this baseline variation is key to advancing cfDNA-based
Tatjana Jatsenko, Kaat Leroy, Koenraad Devriendt   +2 more
exaly   +3 more sources

Diagnostics of lung cancer by fragmentated blood circulating cell-free DNA based on machine learning methods [PDF]

Frontiers in Medicine
IntroductionMinimally invasive diagnostics based on liquid biopsy makes it possible early detection of lung cancer (LC). The blood plasma circulating cell-free DNA (cfDNA) fragments reflect the genome and chromatin status and are considered as integral ...
Ivan O. Meshkov, Alexander P. Koturgin, Pavel V. Ershov, Liubov A. Safonova, Julia A. Remizova, Valentina V. Maksyutina, Ekaterina D. Maralova, Vasilisa A. Astafieva, Alexey A. Ivashechkin, Boris D. Ignatiev, Antonida V. Makhotenko, Ekaterina A. Snigir, Valentin V. Makarov, Vladimir S. Yudin, Anton A. Keskinov, Sergey M. Yudin, Anna S. Makarova, Veronika I. Skvortsova   +17 more
doaj   +2 more sources

Liquid biopsy for early detection of hepatocellular carcinoma [PDF]

Frontiers in Medicine, 2023
Hepatocellular carcinoma (HCC) is a highly prevalent and lethal cancer globally. Over 90% of HCC cases arise in the context of liver cirrhosis, and the severity of the underlying liver disease or advanced tumor stage at diagnosis significantly limits ...
Ioana Manea, Ioana Manea, Ioana Manea, Razvan Iacob, Razvan Iacob, Razvan Iacob, Speranta Iacob, Speranta Iacob, Speranta Iacob, Razvan Cerban, Razvan Cerban, Razvan Cerban, Simona Dima, Simona Dima, Simona Dima, Gabriel Oniscu, Irinel Popescu, Irinel Popescu, Liliana Gheorghe, Liliana Gheorghe, Liliana Gheorghe   +20 more
doaj   +2 more sources

Detection of known gene fusions in cancer cell lines using whole-genome bisulfite sequencing data [PDF]

Scientific Reports
Whole-genome bisulfite sequencing (WGBS) provides multiple molecular information layers including methylation, copy number variations (CNVs), single nucleotide variants (SNVs), and fragmentome patterns in cell-free DNA (cfDNA) while gene fusion detection
Taehoon Kim, Duhee Bang
doaj   +2 more sources

Prognostic significance of circulating tumor DNA in non-metastatic colorectal cancer [PDF]

Discover Oncology
Purpose Circulating tumor DNA (ctDNA) is the small fragments of DNA released by tumor cells into the blood. By detecting the abnormal changes in ctDNA in the blood, it can assist in the early screening of cancer, monitoring of treatment efficacy, early ...
Ruiyang Li, Shuchao Wang, Jie Xu, Min Zhao, Heng Zhang, Yibo Yin, Xue Han, Baojun Liu, Wenjian Liu   +8 more
doaj   +2 more sources

Methodology for Biological Sample Collection, Processing, and Storage in the Newcastle 1000 Pregnancy Cohort: Protocol for a Longitudinal, Prospective Population-Based Study in Australia [PDF]

JMIR Research Protocols
BackgroundResearch in the developmental origins of health and disease provides compelling evidence that adverse events during the first 1000 days of life from conception can impact life course health.
Joshua J Fisher, Tegan Grace, Nathan A Castles, Elizabeth A Jones, Sarah J Delforce, Alexandra E Peters, Gabrielle K Crombie, Emily C Hoedt, Kirby E Warren, Richard GS Kahl, Jonathan J Hirst, Kirsty G Pringle, Craig E Pennell   +12 more
doaj   +2 more sources

A method of comprehensive sequencing analysis of the small RNA fragmentome (RiboMarker) [PDF]

Rna
Aidan C Manning, Sérgio Barberán-Soler, Sergei A Kazakov   +2 more
exaly   +2 more sources